| 抗支原体喹诺酮的合成及其构效关系 |
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| 引用本文： | 杨玉社,嵇汝运,陈凯先,叶辉,武济民.抗支原体喹诺酮的合成及其构效关系[J].药学学报,1999,34(5):349-352. |
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| 作者姓名： | 杨玉社 嵇汝运 陈凯先 叶辉 武济民 |
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| 作者单位： | 中国科学院上海药物研究所,上海,200031 |
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| 摘 要： | 目的：开发新型抗支原体药物。方法与结果：设计合成了一系列新型左旋氧氟沙星类似物(18～24)，测试其体外抗支原体活性(MIC值)，并讨论了他们的构效关系。结论：所合成的化合物有较好的抗支原体活性。哌嗪环或高哌嗪环4位氮原子有吸电子基团时，可能有利于提高喹诺酮的抗支原体活性。
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| 关 键 词： | 左旋氧氟沙星 氟喹诺酮 合成 抗菌活性 |
| 收稿时间： | 1998-04-17 |
| 修稿时间： | : 1998-04- |
STUDIES ON SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF ANTIMYCOPLASMA QUINOLONES |
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| Yang Yushe,Ji Ruyun,Chen Kaixian,Ye Hui,Wu Jimin.STUDIES ON SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF ANTIMYCOPLASMA QUINOLONES[J].Acta Pharmaceutica Sinica,1999,34(5):349-352. |
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| Authors: | Yang Yushe Ji Ruyun Chen Kaixian Ye Hui Wu Jimin |
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| Abstract: | AIM: To develop new antimycoplasma drugs. METHODS and RESULTS: A series of new analogues of (S)(-)ofloxacin with antimycoplasma activities were prepared. Compounds 1824 were new compounds. Their in vitro susceptibilities to mycoplama were tested. The influences on structureactivity relationships were also discussed. CONCLUSION: The synthesized compounds have good activities against mycoplasma. The electronwithdrawing groups on the 4position of piperazine or homopiperazine may be favorable for antimycoplasma activity. |
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| Keywords: | antitmycoplamasa quinolone mycoplasma (S)(-)ofloxacin synthesis |
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