Involvement of μ-opioid receptors and α-adrenoceptors in the immunomodulatory effects of dihydroetorphine

The present study investigated the effects of acutely administered dihydroetorphine on mitogen-stimulated lymphocytes proliferation and lyrnphokine production in mice.These immune functions were significantly suppressed by dihydroetorphine at 24μg·kg~(-1) and 128μ·g-kg~(-1) in a dose-dependent fashion.This study further examined the involvement of μ-opioid receptors and