| 超氧歧化酶和过氧化氢酶对缺血后再灌注心肌的保护 |
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| 引用本文： | 徐志飞 蔡用之. 超氧歧化酶和过氧化氢酶对缺血后再灌注心肌的保护[J]. 第二军医大学学报, 1989, 10(4): 347-351 |
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| 作者姓名： | 徐志飞 蔡用之 |
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| 作者单位： | 长征医院胸外科(徐志飞)，长海医院胸外科(蔡用之，耿振江，张宝仁)，第二军医大学生物化学教研室(陈克明)，第二军医大学生物化学教研室(石颖) |
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| 摘 要： |
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| 关 键 词： | 超氧物歧化酶 过氧化氢酶 心肌保护 |
EFFECT OF SUPEROXIDE DISMUTASE PLUS CATALASE ON PROTECTION OF GLOBALLY ISCHEMIC REPERFUSED ISOLATED RABBIT HEART |
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| Xu Zhifei,et al. EFFECT OF SUPEROXIDE DISMUTASE PLUS CATALASE ON PROTECTION OF GLOBALLY ISCHEMIC REPERFUSED ISOLATED RABBIT HEART[J]. Former Academic Journal of Second Military Medical University, 1989, 10(4): 347-351 |
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| Authors: | Xu Zhifei et al |
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| Abstract: | An experimental model of isolated rabbit working hearts was used to investigate whether supplementing cardioplegic solution with oxygen free radical scavengers exerts protective effect on ischemic and reperfusad heart.Animal hearts wero randomly divided into two groups : simple cardioplegic solution was used in the control group ; cardioplegic solution was supplemented with superoxide dismutase plus catalase in the experimental group.Following 120 min of ischemic arrest and 30 min of reperfusion, recoveries of LVPSP, LVEDP, LV + dp/dt max and LV-dp/dt max, expressed as percentage of preischemic control valu-S, and tissue ATP contjnt w-r significantly better (P<0.05 or 0.01) in the experimental group than that in the control group.The results of this study reveal that superoxide dismutase plus catalase enhances the efficacy of hypother-mic cadioplegia to protect the globally ischemic reperfused heart. |
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| Keywords: | oxygen free radical isolated rabbit heart myocarclial protection |
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