EffectsofCompoundSalviaInjectianonLipidPeroxidationAntioxidantEnzymesActivityinPatientswithChronicCorPulmonale

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Effects of Compound Salvia Injectian on Lipid PeroxidationAntioxidant Enzymes Activity in Patientswith Chronic Cor Pulmonale

The effects ot Compound Salvia lnjection ( CSI ) on plasma lipid peroxidation ( LPO) , RBC su-peroxide dismutase (SOD) , glutathione peroxidase ( GSH-Px) and catalase ( CAT) activity in patients withchronic cor pulmonale were studied. Thirty patients were randomly divided into two groups : the group treatedwith routine therapy ( routine group) and the group treated with routine therapy plus CSI (CSI group) . The 4parameters mentioned abave have been measured in patients of the two groups and in 22 healthy subjects forcontrol. The results showed: ( 1 ) Before treatment, both the treatment groups had significantly higher LPOand SOD and markedly lower GSH-Px and CAT level than those of the healthy control ( P < 0 . 001 ) . (2) Aftertreatment the 4 parameters have been normalized in CSI group. (3 ) In the routine group, the parameterswere still abnormal, that is, the increased levels of GSH-Px and CAT and the decreased LPO were singifi-cantly greater in CSI group than that in routine group. These results indicated that CSI could obviously lowerthe enhanced lipid peroxidation and adjust the imbalance of antioxidant enzymes.