乳腺导管内乳头状瘤癌变的细胞学诊断分析

目的：应用细胞学方法诊断乳腺导管内乳头状瘤（intraductal papillomas,IP)，癌变，并探讨其意义。方法：涂片瑞－姬染色行细胞学检查分析。大部分病例同进做近红外线扫描、B超、乳腺X线检查。结果：IP 128例中，15例发生癌变，占11.7％，均有手术及病理证实，癌变是在IP基础上细胞形态发生了癌细胞样改变。癌变平均年龄48.1岁，血性溢液为主，占73.3％（11／15）。结论：乳头状瘤是乳腺癌的前期病变。故女性年龄超过45岁，特别是绝经后妇女，具有血性溢液者，应考察癌性的发展。

The Cytologic Diagnosis and Analysis of Canceration of Breast Intraductal Papillomas

Objective:The cytologic methods were used in the diagnosis of cancerous change of (intraductal papillomas,IP) and its significance was discussed. Methods: We studied the nipple discharge smear by using Wright Gimsa staining. Meanwhile, infrared ray scanning B ultrasound and X rays were performed. Results: One hundred and twenty eight patients were with IP, among them, 15 (11.7%)were confirmed as tumors by surgery and pathological examination. The cancerous change of cytomorphology was based on IP. The average age of patients with cancerous change was 48.1.The nipple discharge in patients with cancerous change was primarily bloody(66.7%). Conclusion: Introductal papillomas is carcerous. The possibility of canceration in persons with longer time of nipple discharge is larger than those with shorter time of nipple discharge. Women who are elder than 45 years old, with nipple discharge and post menopause, should be considered to have the possibility of cancerous change.