| 精制清开灵注射液对内毒素致大鼠多脏器损伤保护作用的研究 |
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| 引用本文： | 孙明杰,周艳华,隋宇. 精制清开灵注射液对内毒素致大鼠多脏器损伤保护作用的研究[J]. 中国中医基础医学杂志, 2005, 11(11): 828-830 |
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| 作者姓名： | 孙明杰 周艳华 隋宇 |
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| 作者单位： | 中国中医研究院基础理论研究所,北京,100700 |
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| 摘 要： | 目的:考察精制清开灵注射液对内毒素致大鼠多脏器损伤的保护作用.方法:将内毒素500eu/kg(200eu/ml,2.5ml/kg)尾静脉注入大鼠,造成大鼠多脏器损伤,并施以药物治疗.结果:精制清开灵注射液具有明显的抗内毒素作用,恢复内毒素导致的脏器损伤.结论:增强自由基的活力和抑制过氧化损伤是精制清开灵注射液保护机体组织损伤的作用机理之一.
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| 关 键 词： | 精制清开灵注射液 内毒素 动物模型 |
| 文章编号： | 1006-3250（2005）11-0828-03 |
| 收稿时间： | 2005-05-13 |
| 修稿时间： | 2005-05-13 |
Experimental Study of the Protecting Effect of Injection of Refined Qing Kai Ling on the Damnify of Rat Viscera Induced by Endotoxin |
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| SUN Ming-jie,ZHOU Yan-hua,SUI Yu. Experimental Study of the Protecting Effect of Injection of Refined Qing Kai Ling on the Damnify of Rat Viscera Induced by Endotoxin[J]. Chinese Journal of Basic Medicine In Traditional Chinese Medicine, 2005, 11(11): 828-830 |
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| Authors: | SUN Ming-jie ZHOU Yan-hua SUI Yu |
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| Affiliation: | Institute of Basic Theory of TCM, China Academy of TCM, Beijing 100700, China |
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| Abstract: | Objective: To investigate the protecting effect of refined Qing Kai Ling(RQKL) on the damnify of rat viscera induced by endotoxin.Method: The models were induced by injection of endotoxin into the rat and treated by injection of refined Qing Kai Ling.Conclusion: Experimental result revealed the anti-endotoxin Effect of RQKL is definite.The injures in rat lung,heart,kidney,and liver were evidently recoveried by treatment with refined Qing Kai Ling.It's possible pharmacological mechanisms are the enhancing to the free-radical activity and the inhibition to over-oxidation. |
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| Keywords: | Endotoxin Animal model Injection of Qing Kai Ling |
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