Studies on the role of vitamin D in early skeletal development,mineralization, and growth in rats |
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Authors: | Scott C. Miller Bernard P. Halloran Hector F. DeLuca Webster S. S. Jee |
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Affiliation: | (1) Division of Radiobiology, Department of Pharmacology, School of Medicine, University of Utah, 84112 Salt Lake City, Utah, USA;(2) Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin-Madison, 53706 Madison, Wisconsin, USA;(3) Present address: Department of Medicine, School of Medicine, University of California at San Francisco, Veterans Administration Hospital, 4150 Clement St., 94121 San Francisco, California, USA |
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Abstract: | Summary The role of vitamin D in early skeletal development was studied by measuring serum calcium and phosphorus, osseous tissue quantity and mineralization, and endochondral bone elongation in rat fetuses and pups from vitamin D-replete and vitamin D-deficient mothers. At the 20th day of pregnancy there was a slight, yet significant, increase in the amount of osteoid on trabecular bone surfaces in fetuses from vitamin D-deficient mothers. The fetal bones otherwise appeared normal in spite of severe skeletal changes in the vitamin D-deficient mothers. After parturition, the importance of vitamin D in skeletal development becomes progressively more obvious. Serum calcium levels were slightly, yet significantly, lower in vitamin D-deficient than in vitamin D-replete pups and these levels continued to fall in the vitamin D-deficient pups through lactation and after weaning. At 3 days postpartum, there was a small, yet significant, increase in the amount of osteoid on bone surfaces of the vitamin D-deficient pups. The relative amounts of osteoid in the vitamin D-deficient pups continued to increase through lactation and after weaning when compared with vitamin D-replete pups. By the 14th day of lactation and at later periods, there were significant reductions in metaphyseal mineralized tissues in the vitamin D-deficient pups when compared with the vitamin D-replete pups. At weaning and after weaning, there were substantial increases in growth plate thickness and decreases in longitudinal bone growth in the vitamin D-deficient pups when compared with the vitamin D-replete pups. The results from this study indicate that vitamin D does not appear to play a major role in fetal skeletal development. However, after birth, vitamin D becomes progressively more important with age for normal bone development, mineralization, and endochondral growth. |
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Keywords: | Vitamin D Vitamin D deficiency Bone Cartilage Bone development |
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