| 蛋白质组学在白内障研究中的应用 |
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| 引用本文： | 柴飞燕,严宏.蛋白质组学在白内障研究中的应用[J].眼科研究,2006,24(3):327-329. |
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| 作者姓名： | 柴飞燕 严宏 |
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| 作者单位： | 710038,西安,第四军医大学唐都医院眼科 |
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| 摘 要： | 后基因组时代，蛋白质组学作为功能基因组学研究的核心技术之一，已成为生物医学领域强大的技术支撑，并为白内障疾病的研究提供了一个新的平台。白内障和老化被认为是一类构象性疾病。晶状体透明性与具有分子伴侣活性的α-晶体蛋白密切相关。白内障发生时，多种疾病特征性的蛋白质组改变，可导致α-晶体蛋白分子内或分子间的交联，分子伴侣活性下降，加速白内障的形成。就蛋白质组学在白内障发病机制研究中的应用进行综述。
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| 关 键 词： | 白内障 蛋白质组学 翻译后修饰 |
| 文章编号： | 1003-0808（2006）03-0327-04 |
| 收稿时间： | 2005-08-10 |
| 修稿时间： | 2005-08-102006-03-02 |
Application of proteomics in the cataract research |
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| Chai Feiyan..Application of proteomics in the cataract research[J].Chinese Ophthalmic Research,2006,24(3):327-329. |
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| Authors: | Chai Feiyan |
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| Abstract: | Proteomics is one of the critical technologies in functional genomics in post-genome era. It has been the technological foundation in the medical field. Proteomics provides a new way to study cataract. Cataract and aging is believed as a kind of conformational diseases. The transparency is mainly related to the role of molecular chaperone in ~t-crystallin. Appling proteomics, we can detect various of characteristic proteome,which induce intramolecular or extramolecular aggregation in ~t-crystallin and reduce its activity and accelerate the cataract formation. Here application of proteomics in the cataract research is reviewed. |
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| Keywords: | cataract proteomics post-translational modification |
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