血清高敏C反应蛋白与心房颤动

目的探讨炎症与心房颤动的发生和持续的关系。方法心房颤动患者124例,分为两组,慢性心房颤动组53例,阵发性心房颤动组71例,对照组(窦性心律)54例。采用免疫速率散射比浊法测定各组患者血清高敏C-反应蛋白(highsensitivityC-reactiveprotein,hs-CRP)的含量,同时测量各患者左心房前后径。结果慢性心房颤动组患者血清hs-CRP水平高于阵发性心房颤动组(P<0.05)及正常对照组(P<0.01);阵发性心房颤动组患者血清hs-CRP水平高于正常对照组(P<0.05);慢性心房颤动组左心房前后径,与窦性心律组比较差异有统计学意义(P<0.05);阵发性心房颤动组与窦性心律组比较,左心房前后径虽有增大,但差异无统计学意义(P>0.05)。结论hs-CRP水平升高可能参与心房颤动的发生,提示炎症反应具有促进心房颤动的发生和持续的作用。

Correlation analysis of serum high sensitive C-reactive protein with atrial fibrillation

Objectives To explore the correlation between inflammation and occurrence and maintenance of atrial fibrillation. Methods 124 atrial fibrillation patients were divided into two groups:chronic atrial fibrillation group(53 cases), paroxysmal atrial fibrillation group(71 cases), and control group(sinus rhythm, 54 cases). The serum high sensitive C-reactive protein (hs-CRP) content and left atrial diameter(LAd) in each group were measured by immune rate nephelometry and echocardiography. Results The serum hs-CRP level of chronic atrial fibrillation group was higher than that of paroxysmal atrial fibrillation group(P<0.05)and normal control group(P<0.01). The serum hs-CRP level of paroxysmal atrial fibrillation group was higher than that of normal control group(P<0.05). The LAd of chronic atrial fibrillation group was significantly different from that of sinus rhythm group(P<0.05). The LAd of paroxysmal atrial fibrillation group was insignificantly greater than that of sinus rhythm group(P >0.05). Conclusions There is significant increase of hs-CRP level in patients with atrial fibrillation. Thus, it indicates that the inflammatory reaction may promote the occurrence and maintenance of atrial fibrillation.