组织因子表达与直肠癌肝转移及其预后

目的 探讨组织因子（TF）与直肠癌肝转移的关系及其在原发直肠癌中的预后意义。方法 应用免疫组织化学染色法观察40例原发直肠癌组织,3例直肠癌肝转移灶组织和6例直肠良性腺瘤TF的表达特点,结合临床病理资料进行分析。结果 （1）40例原发直肠癌中,20例TF表达阳性,正常黏膜和6例良性腺瘤均无TF表达。（2）直肠癌同时性肝转移和异时性肝转移TF的表达均与肝转移的发生密切相关（P=0.002和P=0。001）.(3)TF是影响原发直肠癌预后的因素之一（P=0.024)。结论 TF可能参与原发直肠癌肝转移的生物学过程,其阳性表达可能作为高危患者术后肝转移的预测指标应用于临床。

Relationship between tissue factor expression and hepatic metastasis and prognosis in rectal cancer

Objective To investigate the correlation between tissue factor (TF) expression and hepatic metastasis and prognosis in rectal cancer. Methods TF expression was retrospectively studied by immunohistochemical method in speci mens of 40 rectal cancer, 3 hepatic metastasis and 6 benign adenoma with relatio n to their clinicopathologic data. Results 1. TF expression was detected in 20(50 %) of the 40 primary rectal cancer specimens and all the 3 hepatic metastatic specimens, but not in the 6 benign adenoma or normal mucosa of rectum, 2. Signi ficant correlation was observed between TF expression and synchronic hepatic me tastasis ( P =0.002)and heterochronic hepatic metastasis ( P =0.001) and 3 .TF was a risk factor for the prognosis of primary rectal cancer ( P =0.024). Conclusion Tissue factor expression may play a role in the process of developing hepatic m etastasis. It may be considered as a new clinical indicator for monitor of hepat ic metastasis and prognosis of primary rectal cancer.