Efficacy of melatonin as protectant against oxidative stress and structural changes in liver tissue in pinealectomized rats |
| |
Authors: | Sahna Engin Parlakpinar Hakan Vardi Nigar Ci?remis Yilmaz Acet Ahmet |
| |
Institution: | Department of Pharmacology, Faculty of Medicine, Firat University, Elazig, Turkey. esahna@hotmail.com |
| |
Abstract: | Previous observations demonstrated that physiological levels of melatonin, the pineal secretory product, are important in protecting against oxidative stress-induced tissue damage. We investigated the effects of pinealectomy and administration of exogenous melatonin on liver tissue in rats. Pinealectomized (Px) and sham-operated (non-Px) rats were used. We evaluated structural changes, reduced glutathione (GSH) levels and malondialdehyde (MDA) levels. Rats were divided into three groups (10 rats in each group): control (non-Px), Px+vehicle and Px+melatonin (4 mg/kg given daily intraperitoneally for 10 days). Liver GSH levels were significantly lower in Px rats than in the control group. Melatonin administration significantly increased GSH levels (p < 0.05). Px caused a significant increase in MDA levels as compared with the control group and melatonin administration to Px rats significantly reduced MDA levels in the liver (p < 0.05). Sinusoidal dilatation to a varying degree developed in all Px rats. Severity of mononuclear cell infiltration and sinusoidal congestion were lower in Px+melatonin group than in the Px group. These findings suggest that a significant increase in oxidative and structural changes occur in rat livers after pinealectomy, which can be diminished by melatonin treatment. |
| |
Keywords: | Melatonin Pinealectomy Glutathione Malondialdehyde Liver |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|