阿立哌唑与舒必利治疗慢性精神分裂症阴性症状随机双盲对照研究

目的：探索阿立哌唑对慢性精神分裂症阴性症状疗效及副反应。方法：对100例以阴性症状为主的慢性精神分裂症住院患者随机分为两组，阿立哌唑组（研究组）50例，舒必利组（对照组）50例，观察期12周，采用阳性与阴性症状量表（PANSS）、阴性症状评定量表（SANS）和临床疗效总评量表（CGI—GI）评定疗效，副反应量表（TESS）计定副作用。结果：阿立哌唑组总有效率86％，舒必利组总有效率72％，两组有显著差异（P〈0．05），而副反应显著低于舒必利。结论：阿立哌唑是治疗以阴性症状为主的慢性精神分裂症较理想的药物。

A comparative study on aripiprezole and sulpiride in treating schizophrenia whose predominant clinical features were negative symptoms

Objective:To explore efficacy and side effect with aripiprezole in the treatment of schizophrenia whose predominant clinical features were negative symptoms.Methods:100 cases of schizophrenia whose predominant clinical features were negative symptoms were randomly assigned to treat with either aripiprezole or sulpiride.Efficacy was assessed by PANSS,SANS,CGI-GI,and side effect by TESS.Results: There was significant difference in efficacy between the groups.Side effect of aripiprezole was significant lower than sulpiride.Conclusions:Aripiprezole is preferred as an ideal medicine in the treatment of Schizophrenia whose predominant Clinical features were negative symptoms.