Platelet activity and cardiovascular risk in apparently healthy individuals: a review of the data |
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Authors: | Gaurav Sharma Jeffrey S Berger |
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Institution: | (1) Divisions of Cardiology and Hematology, Vascular Surgery, Cardiovascular Thrombosis, Department of Medicine, New York University School of Medicine, 530 First Avenue, Skirball 9R, New York, NY 10016, USA; |
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Abstract: | Cardiovascular disease is a major cause of morbidity and mortality. Numerous risk scores exist to identify healthy individuals
at increased risk of developing cardiovascular disease. Although platelets are a key mediator in the pathogenesis of cardiovascular
disease, the role of platelet activity measurements and the incidence of cardiovascular disease are uncertain. Platelet aggregometry—the
most well studied method of platelet function testing—is associated with risk factors for cardiovascular disease. However,
data supporting platelet aggregation and incident cardiovascular disease is conflicting. Plasma markers of platelet activation
are promising candidates. Soluble CD40L and P-selectin are easily measured with a standardized ELISA, and there is some data
to suggest an association with cardiovascular disease, but further studies are required. While mean platelet volume is a promising
candidate, platelet count and bleeding time are not specific for platelet activity nor are they associated with cardiovascular
disease in a healthy population. For this field to progress, we recommend large-scale, prospective studies that measure a
battery of these platelet function tests in individuals without cardiovascular disease to better understand the associations,
if any, between platelet activity and cardiovascular disease. |
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Keywords: | |
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