| 原发性肝癌影响因素的交互作用分析 |
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| 引用本文： | 林少炜,胡志坚.原发性肝癌影响因素的交互作用分析[J].中国全科医学,2011,14(32). |
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| 作者姓名： | 林少炜 胡志坚 |
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| 作者单位： | 福建医科大学公共卫生学院流行病与卫生统计学系, 福建省福州市,350004 |
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| 摘 要： | 目的分析原发性肝癌影响因素间的交互作用。方法采用配对病例对照研究,收集福州地区388例肝癌新发病例和388例对照,使用多因子降维法(MDR)分析因素间的交互作用。根据MDR模型结果,用多因素Lo-gistic回归模型估计交互项及其他危险因素的危险度。结果 MDR最佳模型为乙型肝炎病毒(HBV)感染、吸烟和饮酒的交互作用,该模型的检验样本平衡检验准确度为82.73%,交叉验证一致性为13/15。多因素Logistic回归分析显示,调整了肿瘤史、吃霉变食物和喝茶,HBV感染主效应〔OR=5.722,95%CI(1.809,18.418)〕和交互作用〔OR=5.646,95%CI(1.655,19.259)〕有统计学意义,联合作用也有统计学意义(P<0.05)。结论在原发性肝癌发生过程中,HBV感染是主要因素,吸烟和饮酒是辅助因素,它们协同作用。
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| 关 键 词： | 肝肿瘤 多因子降维法 Logistic模型 交互作用 |
The Interaction between Factors of Primary Liver Cancer |
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| LIN Shao-wei,HU Zhi-jian.The Interaction between Factors of Primary Liver Cancer[J].Chinese General Practice,2011,14(32). |
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| Authors: | LIN Shao-wei HU Zhi-jian |
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| Institution: | LIN Shao-wei,HU Zhi-jian.Department of Epidemiology and Health Statistics,School of Public Health,Fujian Medical University,Fuzhou 350004,China |
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| Abstract: | Objective To explore the interaction between factors of primary liver cancer.Methods A matched case-control study was carried out in Fujian including 388 case with liver canccr and 388 controls.The interaction were analyzed with the MDR model.Base on the result of MDR model,an Logistic regression model was simulated to estimate the ORs of interaction factors and other risk factors.Results The interaction between HBV infection,smoking and drinking was discovered by MDR model with a statistically significant ... |
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| Keywords: | Liver neoplasms Multifactor dimensionality reduction Logistic models Interaction |
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