| 归龙丸方对0级糖尿病足血清基质金属蛋白酶-9、血清同型半胱氨酸的影响研究 |
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| 引用本文： | 王文英,简小兵,伊娜,邓伟明.归龙丸方对0级糖尿病足血清基质金属蛋白酶-9、血清同型半胱氨酸的影响研究[J].中国全科医学,2011,14(34). |
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| 作者姓名： | 王文英 简小兵 伊娜 邓伟明 |
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| 作者单位： | 广州市中医医院内分泌科,广东省广州市,510130 |
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| 基金项目： | 广州市卫生局立项课题(2009-B-07) |
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| 摘 要： | 目的观察归龙丸方早期干预0级糖尿病足(DF)的临床疗效及对周围神经传导速度、血管功能的影响。方法将80例0级DF患者按随机数字表随机分为治疗组和对照组各40例。在基础治疗(口服降糖药或胰岛素注射降糖等)的基础上,治疗组加用归龙丸方治疗,对照组加用西洛他唑口服治疗,观察两组患者治疗前后临床症状评分、踝/肱动脉比(ABI)、双下肢腓总神经传导速度、血清基质金属蛋白酶-9(MMP-9)、血清同型半胱氨酸(Hcy)的变化。结果两组患者临床症状评分治疗后与治疗前比较,差异均有统计学意义(P<0.05);治疗组优于对照组,差异有统计学意义(P<0.05)。治疗组治疗后ABI评分与治疗前比较,差异有统计学意义(P<0.05);对照组患者治疗前后ABI评分间差异无统计学意义(P>0.05);治疗组治疗后ABI评分与对照组比较,差异有统计学意义(P<0.05)。治疗后两组患者腓总神经感觉神经传导速度(SCV)、运动神经传导速度(MCV)与治疗前相比,差异均有统计学意义(P<0.05);治疗组与对照组比较,差异亦有统计学意义(P<0.05)。两组患者治疗后血清MMP-9、Hcy水平与治疗前比较,差异有显著统计学意义(P<0.01...
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| 关 键 词： | 糖尿病足 归龙丸方 踝肱指数 神经传导速度 基质金属蛋白酶-9 同型半胱氨酸 |
Impact of Guilong Pill Formulation in on MMP-9 and Hcy Levels in Patients with Wagner Grade 0 Diabetic Foot |
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| WANG Wen-ying,JIAN Xiao-bing,YI Na,et al..Impact of Guilong Pill Formulation in on MMP-9 and Hcy Levels in Patients with Wagner Grade 0 Diabetic Foot[J].Chinese General Practice,2011,14(34). |
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| Authors: | WANG Wen-ying JIAN Xiao-bing YI Na |
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| Institution: | WANG Wen-ying,JIAN Xiao-bing,YI Na,et al.Department of Endocrine,Guangzhou Hospital of Traditional Chinese Medicine,Guangzhou 510130,China |
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| Abstract: | Objective To observe the therapeutic effects and influence on peripheral nerve conduction velocity and the blood vessel function of Guilong Pill Formulation in early intervention of patients with Wagner grade 0 diabetic foot(DF). Methods Eighty cases suffered from Wagner grade 0 DF were randomized into treatment group and control group,with forty cases each.In addition to basic therapy(blood sugar control with oral western medication or insulin injection),the treatment group was treated with Guilong Pill Fo... |
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| Keywords: | Diabetic foot Guilong pill formulation Ankle brachial index Nerve conduction velocity Matrix metalloproteinases-9 Homocysteine |
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