Effect of the anode and cathode of a direct current on the electrical activity of the isolated node of Ranvier in a medium with low sodium concentration and during the action of Novocain |
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Authors: | V. I. Belyaev |
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Affiliation: | (1) Physiological Laboratory Institute of Surgery of the AMN SSSR, Moscow |
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Abstract: | Summary Experiments were performed on single nerve fibers ofRanatemporaria. The changes in the value and the form of action potential (AP) proved to be similar both in a low-sodium medium and in a Novocain solution. The action of a dc anode on the node of Ranvier in a low-sodium medium caused only an insignificant rise of the AP amplitude but restored the AP completely in a node treated with Novocain. The cathode placed on the node stressed the AP in both cases. The membrane depolarization critical level (CL) rose both in a low-sodium medium and in a Novocain solution. Direct current cathode raised CL to a still greater degree, whereas the anode, on the contrary, lowered it somewhat. However, complete CL restoration did not occur either in a low-sodium medium or in a Novocain solution. The possible mechanism of the changes occurring in the AP and CL amplitudes during dc polarization in a lowsodium medium and in a Novocain is discussed.(Presented by Active Member AMN SSSR A. A. Vishnevskii) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 57, No. 5, pp. 3–6, May, 1964 |
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