| 葛根素注射液对急性脑缺血模型大鼠脑细胞损伤的保护作用 |
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| 引用本文： | 潘洪平杨嘉珍,莫祥兰,李吕力,黄振录,叶劲,黄进.葛根素注射液对急性脑缺血模型大鼠脑细胞损伤的保护作用[J].中国中药杂志,2005,30(6):457-459. |
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| 作者姓名： | 潘洪平杨嘉珍 莫祥兰 李吕力 黄振录 叶劲 黄进 |
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| 作者单位： | 广西壮族自治区人民医院,广西,南宁,530021 |
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| 基金项目： | 广西壮族自治区卫生厅医药卫生科研课题(Z2001072) |
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| 摘 要： | 目的:探讨葛根素注射液对急性脑缺血模型大鼠脑细胞损伤的保护作用。方法:采用闭夹大脑中动脉造成局部脑缺血模型,对实验标本作HE染色后观察其脑组织的病理学改变。结果:葛根素干预组死亡神经元数明显少于单纯缺血组(P<0.05),同时脑水肿程度明显较轻。结论:葛根素对大鼠急性脑缺血损伤有保护作用。
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| 关 键 词： | 葛根素注射液 急性脑缺血模型 大鼠 |
| 文章编号： | 1001-5302(2005)06-0457-03 |
| 收稿时间： | 2004/8/26 0:00:00 |
Protection of puerarin on the cerebral injury in the rats with acute local ischemia |
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| PAN Hong-ping;YANG Jia-zhen;MO Xiang-lan;LI Lu-li;HUANG Zhen-lu;YE Jing;HUANG Jin.Protection of puerarin on the cerebral injury in the rats with acute local ischemia[J].China Journal of Chinese Materia Medica,2005,30(6):457-459. |
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| Authors: | PAN Hong-ping;YANG Jia-zhen;MO Xiang-lan;LI Lu-li;HUANG Zhen-lu;YE Jing;HUANG Jin |
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| Institution: | People's Hospital of Guangxi Autonomous Region, Nanning 530021, China. php1968@126.com |
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| Abstract: | Objective: To study the protection of puerarin on the cerebral injury in the rats with acute local ischemia. Method: Rat model of acute local cerebral ischemia was made by ligating middle cerebral artery. The cerebral damage was evaluated by staining with hematoxylin and eosin((HE). Result: The number of died neurons were significantly less in puerarin-treated rats than in the rats with cerebral ischemia (P<0. 05). Similarly,the cerebral edema were significantly attenuated in the puerarin-treated rats as compared with cerebrally ischemic rats. Conclusion: Puerarin can prevent the neuron from damage induced by acute cerebral ischemia. |
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| Keywords: | puerarin injection acute cerebral ischemia model rat |
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