细胞骨架生物力学模型

细胞骨架力学问题是细胞生物力学发展中出现的一个新领域。细胞骨架模型的建立是理解力在细胞内传播和分布对生化事件调控及力对细胞功能调节的重要手段。细胞骨架也是力和信息传递的介质,作用力通过细胞骨架内外肌动蛋白网架的相连介导化学反应和信号转导。作者详细介绍了基于力学和生物学的三种细胞骨架模型的理论、方法和关键性研究成果。

Biomechanical models of cytoskeleton

Cytoskelelon biomechanics has emerged as a new field of cell mechanics. The cytoskeleton modeling is critical for investigating the transduclion and distribution of mechanical forces in cell, which is fundamental to cell function and biochemical events. Cytoskeleton is also the transduction medium of forces and biochemical signals. The applied mechanical forces control the chemical reaction and signal transduction through the interconnected aetin cyloskeletal network. In this paper, we review three major models, approachs and key accomplishments in cytoskeleton mechanics from a mechanical point.