Platelet‐rich plasma limits the nerve injury caused by 10% dextrose in the rabbit median nerve |
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Authors: | Gi‐Young Park MD PhD Dong Rak Kwon MD PhD |
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Institution: | Department of Rehabilitation Medicine, Catholic University of Daegu School of Medicine, , Nam‐Gu, Daegu, 705‐718 Korea |
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Abstract: | Introduction: We evaluated the effect of platelet‐rich plasma (PRP) injection in a rabbit model of dextrose‐induced median nerve injury. Methods: New Zealand white rabbits (n = 15) were divided randomly into 3 groups. Three different regimens (group 1: 0.1 ml saline; group 2: 10% dextrose with PRP; group 3: 10% dextrose with saline) were injected within the carpal tunnel. Electrophysiological and histological findings were evaluated 12 weeks after the injection. Results: The mean median motor latency in group 3 was significantly longer than that in groups 1 and 2. The cross‐sectional area of the median nerve and subsynovial connective tissue thickness in group 3 were significantly larger than those in groups 1 and 2. Conclusions: PRP injection may be effective in controlling median nerve injury, as demonstrated by improvement in electrophysiological and histological findings 12 weeks after dextrose injection. Muscle Nerve 49 : 56–60, 2014 |
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Keywords: | carpal tunnel dextrose median nerve platelet‐rich plasma rabbit |
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