不同剂量辛伐他汀降脂疗效的比较

目的：比较不同剂量辛伐他汀（舒降之）的降脂疗效。方法：79例患者随机分为A、B两组，A组10mg.d^-1,B组20mg.d^-1，疗程均为8周。结果：治疗前比较，A组血清总胆固醇（TC）、甘油三酯（TG）、低脂蛋白胆固醇（LDL－C）分别下降23．4％，20．0％、30．7％（P均＜0．01），高密度脂蛋白胆固醇（HDL－C升高）17．5％；B组TC、TG和LDL－C分别下降32．75，22．8％，42．8％（P＜0．01），HDL－C升高13．7％，A组中TC、TG和LDL－C达标率分别为12．85，28．2％，15．4％，B组分别为65．05，57．5％，65．0％，疗程中患者均能很好耐受，未见明显不良反应。结论：口服辛伐他汀20mg.d^-1，降脂疗效显著，达标率高。

Effect of Different Doesof Simvastatin in Reducing Serum Lipid

Objective:Comparing the effect of different doses of simvastatin in lowering the serum lipid.Methods:79 patients were randomized into group A and group B,and were given simvastatin 10 mg*d-1 (group A) and 20 mg*d-1 (group B),respectively for a total of 8 weeks.Results:Comparing with baseline,in group A,TC,TG,LDL-C were decreased by 23.4%,20.0% and 30.7%,respectively (P＜0.01); HDL-C was increased by 17.5%.The content of serum TC,TG and LDL-C was decreased to the normal range in 12.8%,28.2% and 15.4% of the patients in group A.For the group B,TC,TG,LDL-C were decreased by 32.7%,22.8% and 42.8%,respectively (P＜0.01); HDL-C was increased by 13.7%.The content of serum TC,TG and LDL-C was decreased to the normal range in 65.0%,57.5% and 65.0% of the group B patients.Conclusion:Oral intake of 20 mg of simvastatin once a day can effectively reduce the serum lipid.The patients can well tolerate and no obvious side effect was observed in our study.