| Antibodies against alpha-fodrin in Sjögren's syndrome |
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| 引用本文： | Ulbricht KU,Schmidt RE,Witte T. Antibodies against alpha-fodrin in Sjögren's syndrome[J]. Autoimmunity reviews, 2003, 2(2): 109-113. DOI: 10.1016/S1568-9972(03)00002-8 |
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| 作者姓名： | Ulbricht KU Schmidt RE Witte T |
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| 摘 要： |
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| 收稿时间： | 2002-11-15 |
Antibodies against alpha-fodrin in Sjögren's syndrome |
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| Ulbricht Kai U,Schmidt Reinhold E,Witte Torsten. Antibodies against alpha-fodrin in Sjögren's syndrome[J]. Autoimmunity reviews, 2003, 2(2): 109-113. DOI: 10.1016/S1568-9972(03)00002-8 |
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| Authors: | Ulbricht Kai U Schmidt Reinhold E Witte Torsten |
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| Affiliation: | Abteilung Klinische Immunologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. |
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| Abstract: | Alpha-fodrin is a part of the membrane skeleton and expressed in the majority of mammalian cells. It is cleaved in apoptosis by caspase 3. One of the cleavage products, a 120-kDa protein, represents a neoantigen. Antibodies against that cleavage product of alpha-fodrin have originally been described in a murine model of Sjögren's syndrome. In addition, they are also present in up to 93% of patients with Sjögren's syndrome, depending on the stringency of the classification used. Although antibodies against alpha-fodrin are observed in other diseases characterized by chronic apoptosis, they are a valuable laboratory marker in the evaluation of Sjögren's syndrome. |
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