Biological actions of nerve growth factor in the peripheral nervous system |
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Authors: | Rask C A |
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Institution: | Genentech, Inc., South San Francisco, Calif. 94080, USA. rask.cynthia@gene.com |
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Abstract: | Since the discovery of nerve growth factor (NGF), its role in the physiology/pathophysiology of nerve function has been under intense investigation. More recently, the potential of recombinant human NGF (rhNGF) as a putative treatment for peripheral neuropathies, in particular diabetic polyneuropathy and HIV-associated sensory neuropathy, is being explored. In animal models of diabetes, depletion of endogenous NGF levels has been demonstrated in foot skin and skeletal muscle; these levels reduce further with increasing disease duration. Preclinical studies in animal models of diabetes have shown that administration of NGF can reverse or alleviate impairment in nerve function. |
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