| HPCE法测定氧氟沙星滴眼液的含量 |
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| 引用本文： | 曾祥林,梁佳,卢日刚. HPCE法测定氧氟沙星滴眼液的含量[J]. 中国药师, 2009, 12(11): 1582-1583 |
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| 作者姓名： | 曾祥林 梁佳 卢日刚 |
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| 作者单位： | 1. 广西食品药品检验所,南宁,530021
2. 广西中医学院 |
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| 摘 要： | 目的：建立高效毛细管电泳法测定氧氟沙星滴眼液的含量。方法：石英毛细管（40cm×50um），运行缓冲溶液为80mmol·L^-1磷酸缓冲液，分离电压为15KV；压力进样5s；柱温25℃；检测波长254nm。结果：氧氟沙星的线性范围0．03～0．36mg·ml^-1（r=0．9992）；平均回收率为99．9％（RSD=0．4％，n=6）。结论：方法简便快捷，可控制氧氟沙星滴眼液的质量。
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| 关 键 词： | 氧氟沙星滴眼液 高效毛细管电泳法 含量测定 |
Determination of Ofloxacin Eye Drops by HPCE |
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| Zeng Xianglin,Liang Jia,Lu Rigang. Determination of Ofloxacin Eye Drops by HPCE[J]. China Pharmacist, 2009, 12(11): 1582-1583 |
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| Authors: | Zeng Xianglin Liang Jia Lu Rigang |
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| Affiliation: | Zeng Xianglin, Liang Jia, Lu Rigang( 1. Guangxi Institute for Food and Drug Control, Nanning, 530021, China ; 2. Guangxi University of Traditional Chinese Medicine) |
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| Abstract: | Objective： To establish an HPCE method for determination the content of ofloxacin eye drops. Method： The quarts capillary （40cm×50um） was used, the separation voltage was 15 kV, the running buffer solution was 80mmol·L^-1 phosphate solution, the sample was injected by pressure for 5s, the separation temperature was 25 ℃, the detection wavelength was 254nm. Result： The linear range of ofloxacin was 0.03 - 0.36mg·ml^-1 （ r = 0.999 2）, the average recovery was 99.9%, RSD 0.4% （ n = 6 ）. Conclusion： This method is simple and quick,it can be used for quality control of ofloxacineye eye drops. |
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| Keywords: | Ofloxacin Eye drops HPCE Determination |
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