儿童结核病短程化疗中的药物毒性观察

为探讨儿童结核病短程化疗中药物的毒副作用及儿童的耐受性，对61例结核病患儿采用治疗前后检查肝，肾功能，尿常规，脑干测听或听力测定，观察（6－9）个月，结果显示年龄在7个月以上小儿毒副作用发生率小于2％，治疗期间无产重毒副作用发生，7个月以下患儿7例儿童中5例出现ALT，AST改变，提示严格掌握多药联用剂量的情况下，一般患儿对短程化疗能很好耐受，年龄在7个月以下婴儿加用保肝治疗仍然能接受短程化疗。

Observative study on drug-toxicity of short-term chemotherapy in children with tuberculosis

In order to explore the drug-toxicity of short-term chemotherapy and the tolerance to these drugs in children with tuberculosis. Hepatic and renal function tests, urine routine and brain-stem audiotory evoked potential or audio-metry have been prospectively assessed prior to and during the therapy in an interval of 6-9 months in 61 cases with tuberculosis. The results obtained indicated that the incidence of toxic and adverse reaction due to chemotherapy was found to be as low as 2%. No toxic reaction appeared during chemotherapy in affected children at the age of greater than 7 months. Otherwise, as increase in ALT and AST levels could be found in 5/7 affected cases at the age of less than 7 months. Through this observation , it is then suggested that no toxic reaction of short-term chemotherapy could take place in children at the age of greater than 7 months if combined drug-dosages are well controlled t whileas, even in children at the age of less than 7 months, this chemotherapy is also acceptable when an additional management of liver protection is rationally adopted.