儿童白血病致病危险因素分析

目的探讨引起儿童白血病的可能危险因素。方法设计白血病发病的危险因素调查表,对2008年5月至2009年2月重庆医科大学附属儿童医院住院的143例白血病患儿与同期住院的108例非白血病患儿进行对照研究,对所得资料进行单因素分析,并选择其中有统计学意义的因素进行多因素条件logistic回归分析。结果单因素分析26项指标中12项有统计学意义（P〈0.05）,其中既往频繁感染病史、油漆汽油接触史、家中进行装修、新皮鞋接触史、家族肿瘤病史、母亲生育年龄、辐射暴露史、农药接触史等8项指标在多因素条件logistic回归分析中有统计学意义（P〈0.05）。结论结果中频繁感染病史等8项指标与白血病的发病密切相关,可能为引起儿童白血病较显著的危险因素。

Dependablity Investigation of the Risk Factors of Childhood Leukaemia

Objective To investigate the risk factors of childhood leukaemia.Methods Questionnaire about risk factors of childhood leukaemia was devised and used.We surveyed and analyzed the relevant risk factors of 143 cases of leukaemia children in Children＇s Hospital of Chongqing Medical University from May 2008 to February 2009,comparing with 108 hospitalized cases without leukaemia during the same period.The significant factors were identified by single factor analysis.Then multi-factors conditional logistic regression analysis was conducted.Results In the single factor analysis,12 of 26 indexes were statistically significant （P0.05）,while in the multi-factors logistic regression analysis,there were 8 of 12 indexes with significance （P0.05）,which of those are frequent infection history,house decoration,family history of cancer,maternal childbearing age,and history of contact with paint,leather shoes,radiation and pesticides.Conclusion The 8 indexes as listed above are closely related to the pathogeny of leukaemia and may be the distinguished risk factors of childhood leukaemia.