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| 乙酰肝素酶和基质金属蛋白酶-9蛋白在皮肤黑素瘤中的表达 | |
| 引用本文： | 陈燕辉,于建斌,张江安,李琳,陈建立.乙酰肝素酶和基质金属蛋白酶-9蛋白在皮肤黑素瘤中的表达[J].中国皮肤性病学杂志,2009,23(9). |
| 作者姓名： | 陈燕辉 于建斌 张江安 李琳 陈建立 |
| 作者单位： | 1. 郑州大学第一附属医院皮肤科,河南,郑州,450052;郑州人民医院皮肤科,河南,郑州,450003 2. 郑州大学第一附属医院皮肤科,河南,郑州,450052 3. 郑州儿童医院皮肤科,河南,郑州,450000 4. 黄河中心医院皮肤科,河南,郑州,450000 |
| 摘 要： | 目的探讨乙酰肝素酶和基质金属蛋白酶-9蛋白在皮肤黑素瘤中的表达及其意义。方法应用免疫组化S-P法检测乙酰肝素酶和基质金属蛋白酶-9蛋白在皮肤黑素瘤30例、交界痣30例及15例正常皮肤组织中的表达。结果皮肤黑素瘤中乙酰肝素酶(63.3%)和基质金属蛋白酶-9蛋白(73.3%)的阳性表达率明显高于交界痣(6.6%)和正常对照组(0)(P均<0.05),交界痣与正常对照组相比,差异无统计学意义(P>0.05)。结论乙酰肝素酶和基质金属蛋白酶-9蛋白的高表达可能与皮肤黑素瘤的发生发展有关,有望作为治疗黑素瘤的靶点。 |
| 关 键 词： | 皮肤黑素瘤 乙酰肝素酶 基质金属蛋白酶-9 |
Expression of Heparanase and Matrix Metalloproteinases-9 in Cutaneous Melanoma |
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| CHEN Yan-hui,YU Jian-bin,ZHANG Jiang-an,LI Lin,CHEN Jian-li.Expression of Heparanase and Matrix Metalloproteinases-9 in Cutaneous Melanoma[J].The Chinese Journal of Dermatovenereology,2009,23(9). | |
| Authors: | CHEN Yan-hui YU Jian-bin ZHANG Jiang-an LI Lin CHEN Jian-li |
| Abstract: | Objective To investigate the expression of heparanase(Hpa)and matrix metalloproteinases-9(MMP-9)protein in cutaneous melanoma(CMM).Methods The expression of Hpa and MMP-9 protein in 30 specimens of CMM,30 specimens of junctional nevus and 15 specimens of normal skin tissues were detected by immunohistochemical S-P method.Results The positive-expression rate of Hpa and MMP-9 protein in CMM was significantly higher than that in junctional nevus and normal skin tissues(P all<0.05).However there was no significant difference in positive-expression rate of Hpa and MMP-9 between the latter two groups(junctional nevus and normal skin tissues)(P>0.05).Conclusion Elevated expression of Hpa and MMP-9 protein may play a potential role in the pathogenesis of CMM.Therefore,Hpa and MMP-9 protein may have significant therapeutic implications as molecular target. |
| Keywords: | Cutaneous malignant melanoma Heparanase Matrix metalloproteinases-9 |
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