系统性红斑狼疮红细胞免疫功能的研究

测定25例活动期和22例缓解期系统性红斑狼疮病人红细胞免疫功能。结果发现,活动期病人红细胞C_3受体活性明显低于对照组(P<0.01)和缓解期病人(P<0.01。活动期病人红细胞表面免疫复合物明显高于对照组(P<0.01)和缓解期病人(P<0.01)。活动期病人红细胞免疫粘附促进因子活性明显低于正常对照组(P<0.01),而红细胞免疫粘附抑制因子活性则明显高于对照组(P<0.01)。此外,还发现系统性红斑狼疮病人红细胞C-3b受体活性与外周血淋巴细胞产生白细胞介素2活性以及与血C_3呈正相关,与血清γ球蛋白呈负相关。结果提示,红细胞C_3b受体活性的降低。可能是导致系统性红斑狼疮发病的因素之一。红细胞免疫功能状态对判断本病的活动及转归,可能有一定的参考意义。

RED CELL IMMUNE IN SYSTEMIC LUPUS ERYTHEMATOSUS

Red cell immune functions were measured in 25 active and 22 remissive systemic lupus erythematosus (SLE) patients. The activity of erythrocyte C3b receptor (E-C3bR) in active SLE was significantly lower than that of normal controls ( P<0.01 ) and that of remissive SLE ( P<0.01 ) . The level of immune complexes on erythrocytes (E-IC) in active SLE increased more significantly than that of normal controls ( P<0.01 ) and remissive SLE ( p<0.01 ) .The erythrocyte immune adherence enhancing factor (EIAEF) in active SLE was significantly lower than that of normal controls ( p<0.01 ). The activity of erythrocyte immune adherence inhibiting factor (EIAIF) in active SLE was significantly higher than that of normal controls ( P<0.01 ) . E-C3bR activity in SLE was negatively correlated with the level of gamma globin, positively correlated with the level of C3 and positively correlated with interleukin-2 (IL-2) activity. These results indicate that deficiency of E-C3bR may play a role in the pathogenesis of SLE and the tests studies of red cell immune function may well serve as a diagnostic criteria for the various stages in the disease course of SLE.