Peripheral Bone Mass is Not Affected by Winter Vitamin D Deficiency in Children and Young Adults from Ushuaia |
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Authors: | M B Oliveri A Wittich C Mautalen A Chaperon A Kizlansky |
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Institution: | (1) Sección Osteopatías Médicas, Hospital de Clínicas, Universidad de Buenos Aires, Córdoba 2351 (1120) Buenos Aires, Argentina and Servicio Clínica Medica, Hospital Regional de Ushuaia, Buenos Aires, Argentina, AR |
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Abstract: | Low vitamin D levels in elderly people are associated with reduced bone mass, secondary hyperparathyroidism, and increased
fracture risk. Its effect on the growing skeleton is not well known. The aim of this study was to evaluate the possible influence
of chronic winter vitamin D deficiency and higher winter parathyroid hormone (PTH) levels on bone mass in prepubertal children
and young adults. The study was carried out in male and female Caucasian subjects. A total of 163 prepubertal children (X
age ± 1 SD: 8.9 ± 0.7 years) and 234 young adults (22.9 ± 3.6 years) who had never received vitamin D supplementation were
recruited from two areas in Argentina: (1)Ushuaia (55° South latitude), where the population is known to have low winter 25OHD
levels and higher levels of PTH in winter than in summer, and (2)Buenos Aires (34°S), where ultraviolet (UV) radiation and
vitamin D nutritional status in the population are adequate all year round. Bone mineral content (BMC) and bone mineral density
(BMD) of the ultradistal and distal radius were measured in the young adults. Only distal radius measurements were taken in
the children. Similar results were obtained in age-sex matched groups from both areas. The only results showing significant
difference corresponded to comparison among the Ushuaian women: those whose calcium (Ca) intake was below 800 mg/day presented
lower BMD and BMC values than those whose Ca intake was above that level (0.469 ± 0.046 versus 0.498 ± 0.041 g/cm2, P < 0.02; 3.131 ± 0.367 versus 3.339 ± 0.386 g, P < 0.05, respectively). In conclusion, peripheral BMD and BMC were similar in children and young adults from Ushuaia and Buenos
Aires in spite of the previously documented difference between both areas regarding UV radiation and winter vitamin D status.
BMD of axial skeletal areas as well the concomitant effect of a low Ca diet and vitamin D deficiency on the growing skeleton
should be studied further.
Received: 7 June 1999 / Accepted: 22 March 2000 |
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Keywords: | : Peripheral bone mass — Childhood bone mass — Peak bone mass — Vitamin D deficiency |
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