| 气相色谱法测定格列齐特中残留乙醇和N,N-二甲基甲酰胺的量 |
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| 引用本文： | 孙红英,王本晓.气相色谱法测定格列齐特中残留乙醇和N,N-二甲基甲酰胺的量[J].齐鲁药事,2007,26(2):88-90. |
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| 作者姓名： | 孙红英 王本晓 |
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| 作者单位： | 山东省医药工业研究所,济南,250100 |
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| 摘 要： | 目的建立格列齐特中残留乙醇和N,N-二甲基甲酰胺的测定方法。方法应用气相色谱法,氢火焰离子化检测器,检测器温度为250℃。结果乙醇的线性范围为0.128～1.02mg.ml-1,r=0.9997,回收率为98.9%,RSD=0.63%(n=6)。N,N-二甲基甲酰胺的线性范围为43.8～175.2μg.ml-1,r=0.9998,回收率为98.2%,RSD=1.12%(n=6)。样品中只检出乙醇。结论该方法简单、准确。
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| 关 键 词： | 气相色谱 格列齐特 乙醇 N N-二甲基甲酰胺 |
| 文章编号： | 1672-7738(2007)02-0088-03 |
Determination of ethanol and DMF remained in Gliclazide |
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| SUN Hong-ying,WANG Ben-xiao.Determination of ethanol and DMF remained in Gliclazide[J].qilu pharmaceutical affairs,2007,26(2):88-90. |
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| Authors: | SUN Hong-ying WANG Ben-xiao |
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| Abstract: | OBJECTIVE Establish a method to determine ethanol and DMF remaining in gliclazide.METHODS Chromatograph-gas was used,flame ionization detector temperature was 250℃.RESULTS In the sample of gliclazide,only the ethanol was detected.The linear range of ethanol was 0.128～1.02mg·ml-1,r=0.9997,the average recovery of ethanol was 98.9%,RSD=0.63%(n=6) .The linear range of DMF was 43.8～175.2μg·ml-1,r=0.9998,the average recovery rate of DMF was 98.2%,RSD=1.12%(n=6).CONCLUSION The method was simple and accurate. |
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| Keywords: | GC gliclazide ethanol DMF |
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