Plasma and cerebrospinal fluid α-MSH levels in the rat after hypophysectomy and stimulation of pituitary α-MSH secretion |
| |
Authors: | A.J. Thody A.A. De Rotte T.J.B. Van Wimersma Greidanus |
| |
Affiliation: | 1. Department of Dermatology, University of Newcastle upon Tyne, NEI 4LP, England;1. Rudolf Magnus Institute for Pharmacology, Medical Faculty, State University of Utrecht Vondellaan 6, Utrecht, The Netherlands |
| |
Abstract: | Immunoreactive α-MSH was measured in cerebrospinal fluid (CSF) and plasma of rats. While treatment with haloperidol increased α-MSH levels in the plasma concentration of α-MSH in the CSF showed little change. Hypophysectomy also had little effect on the concentration of α-MSH in the CSF despite the fall in plasma α-MSH levels. This lack of correlation between α-MSH levels in the CSF and plasma suggests that the systemic circulation does not deliver α-MSH to the CSF. The apparently normal levels of α-MSH in the hypothalamus after hypophysectomy suggests that this tissue is able to synthesize α-MSH and it is possible that the hypothalamus is a source of the α-MSH in the CSF. |
| |
Keywords: | Cerebrospinal fluid α -MSH |
本文献已被 ScienceDirect 等数据库收录! |