| 喉癌中肝细胞再生磷酸酶-3的表达及与微血管密度的相关性 |
| |
| 引用本文： | 胡海丽,董雪蕾,田秀芬. 喉癌中肝细胞再生磷酸酶-3的表达及与微血管密度的相关性[J]. 天津医药, 2011, 39(6): 496-498. DOI: 10.3969/j.issn.0253-9896.2011.06.006 |
| |
| 作者姓名： | 胡海丽 董雪蕾 田秀芬 |
| |
| 作者单位： | 1. 郑州大学第三附属医院耳鼻喉科,450052
2. 郑州大学第一附属医院耳鼻喉科 |
| |
| 基金项目： | 郑州市科技局普通攻关2008资助项目 |
| |
| 摘 要： | 目的:探讨在喉鳞状细胞癌中肝细胞再生磷酸酶-3(PRL-3)和微血管密度(MVD)的相关性。方法:采用免疫组化SABC法检测69例喉鳞状细胞癌组织和25例相应癌旁组织中PRL-3的表达情况,并用CD105标记MVD,研究PRL-3的表达及MVD计数与喉鳞癌临床病理特征的关系,采用Spearman等级相关分析PRL-3表达与MVD的相关性。结果:PRL-3在癌组织中的阳性表达率(65.22%)高于癌旁组织(8%),差异有统计学意义(P<0.01)。癌组织中有淋巴结转移患者的PRL-3阳性率和MVD计数明显高于无淋巴结转移患者,病理分期为Ⅲ~Ⅳ期的PRL-3和MVD高于Ⅰ~Ⅱ期,差异均有统计学意义(P<0.05)。PRL-3的表达与MVD计数呈正相关(r=0.811,P<0.01)。结论:PRL-3可能作为一种新的肿瘤标志物来监控喉鳞状细胞癌的发生、浸润和转移。
|
| 关 键 词： | 肿瘤,鳞状细胞 喉肿瘤 癌 磷酸单酯水解酶类 新生血管化,病理性 免疫组织化学 |
The Expression and Significance of Phosphatase of Regenerating Liver-3 and Microvessel Density in Laryngeal Squamous Cell Carcinoma |
| |
| HU Haili,DONG Xuelei,TIAN Xiufen. The Expression and Significance of Phosphatase of Regenerating Liver-3 and Microvessel Density in Laryngeal Squamous Cell Carcinoma[J]. Tianjin Medical Journal, 2011, 39(6): 496-498. DOI: 10.3969/j.issn.0253-9896.2011.06.006 |
| |
| Authors: | HU Haili DONG Xuelei TIAN Xiufen |
| |
| Affiliation: | HU Haili,DONG Xuelei,TIAN XiufenDepartment of Otolaryngology,The Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China |
| |
| Abstract: | Objective:To evaluate the role of phosphatase of regenerating liver-3(PRL-3) and microvessel density (MVD) in laryngeal squamous cell carcinoma, and their relationship thereof. Methods: The expression level of PRL-3 was detected by immmuno-histochemical SABC method in tissue samples of 69 laryngeal carcinoma and 25 corresponding adjacent tissues. MVD was marked by CD105. The relationship between expression of PRL-3, the count of MVD and the clinicopathologic parameters of laryngeal squamous cell carcinoma w... |
| |
| Keywords: | neoplasms squamous cell laryngeal neoplasms carcinoma phosphoric monoester hydrolases neovascularization pathologic immunohistochemistry |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《天津医药》浏览原始摘要信息 |
|
点击此处可从《天津医药》下载全文 |
