手术患者内嵌Schnider药代动力参数异丙酚靶控输注系统准确性的评价

目的 评价手术患者内嵌Schnider药代动力参数异丙酚TCI系统的准确性.方法择期腹腔镜下妇科手术患者40例,ASA分级Ⅰ或Ⅱ级,年龄25～45岁,体重指数20～25 kg/m2.麻醉诱导:TCI异丙酚(血浆靶浓度3μg/ml)和瑞芬太尼(血浆靶浓度4 ng/ml),意识消失后静脉注射罗库溴铵0.6 mg/kg,气管内插管后行机械通气,调整通气参数,维持PETCO2 30～40mm Hg.麻醉维持:TCI瑞芬太尼(血浆靶浓度4 ng/ml),调节异丙酚血浆靶浓度3～5μg/ml,维持BIS值40～45,间断静脉注射阿曲库铵0.2 mg/kg.于建立气腹后15、30、45、60 min时采集静脉血样,采用高效液相色谱-荧光法测定异丙酚血药浓度,计算TCI系统的执行误差、偏离度、精确度、分散度和摆动度.结果 TCI系统的执行误差为21%(13%),偏离度为6.7%(37.4%),精确度为19%(18%),分散度为-0.65%/h(0.82%/h),摆动度为16.3%(15.2%).结论 手术患者内嵌Schnider药代动力参数异丙酚TCI系统的准确性较高,可满足临床要求.

Abstract：

Objective To evaluate the predictive performance of propofol target-controlled infusion (TCI) system incorporating the Schnider pharmacokinetic parameters in Chinese patients. Methods Forty ASA Ⅰ or Ⅱ patients, aged 25-45 yr, with body mass index 20-25 kg/m2 , scheduled for gynecological laparoscopic surgery un der general anesthesia, were enrolled in this study. Anesthesia was induced with TCI of propofol (target plasma concentration (Cp) 3 μg/ml) and remifentanil (Cp 4 ng/ml) . Propofol was infused by Orchestra TCI system incorporating the Schnider pharmacokinetic parameters. Tracheal intubation was facilitated with rocuronium 0.6 mg/kgafter the patients lost consciousness. The patients were mechanically ventilated. PETCO2 was maintained at 30-40 mm Hg. Anesthesia was maintained with TCI of remifentanil (Cp 4 ng/ml) and propofol (Cp 3-5 μg/ml) and intermittent iv boluses of atracurium 0.2 mg/kg. BIS value was maintained at 40-45. Venous blood samples were obtained at 15, 30, 45 and 60 min after pneumoperitoneum for measurement of blood propofol concentrations by high performance liquid chromatography with fluorescence detector. Performance error, median prediction performance error, median absolute performance error, wobble and divergence of propofol TCI system were calculated. Results The value for performance error was 21 % (13%), for median prediction performance error 6.7 % (37.4%),for median absolute performance error 19% (18%), for divergence - 0.65%/h (0.82%/h) and for wobble 16.3% (15.2% ) . Conclusion The accuracy of propofol TCI system incorporating the Schnider pharmacokinetic parameters is high in Chinese patients and its predictive performance is acceptable clinically.

Evaluation of predictive performance of propofol target-controlled infusion system incorporating the Schnider pharmacokinetic parameters

Objective To evaluate the predictive performance of propofol target-controlled infusion (TCI) system incorporating the Schnider pharmacokinetic parameters in Chinese patients. Methods Forty ASA Ⅰ or Ⅱ patients, aged 25-45 yr, with body mass index 20-25 kg/m2 , scheduled for gynecological laparoscopic surgery un der general anesthesia, were enrolled in this study. Anesthesia was induced with TCI of propofol (target plasma concentration (Cp) 3 μg/ml) and remifentanil (Cp 4 ng/ml) . Propofol was infused by Orchestra TCI system incorporating the Schnider pharmacokinetic parameters. Tracheal intubation was facilitated with rocuronium 0.6 mg/kgafter the patients lost consciousness. The patients were mechanically ventilated. PETCO2 was maintained at 30-40 mm Hg. Anesthesia was maintained with TCI of remifentanil (Cp 4 ng/ml) and propofol (Cp 3-5 μg/ml) and intermittent iv boluses of atracurium 0.2 mg/kg. BIS value was maintained at 40-45. Venous blood samples were obtained at 15, 30, 45 and 60 min after pneumoperitoneum for measurement of blood propofol concentrations by high performance liquid chromatography with fluorescence detector. Performance error, median prediction performance error, median absolute performance error, wobble and divergence of propofol TCI system were calculated. Results The value for performance error was 21 % (13%), for median prediction performance error 6.7 % (37.4%),for median absolute performance error 19% (18%), for divergence - 0.65%/h (0.82%/h) and for wobble 16.3% (15.2% ) . Conclusion The accuracy of propofol TCI system incorporating the Schnider pharmacokinetic parameters is high in Chinese patients and its predictive performance is acceptable clinically.