| 慢性荨麻疹患者血清二胺氧化酶活性和总IgE检测及意义 |
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| 引用本文： | 张敏,李桂珍,宋蒙蒙,张理涛.慢性荨麻疹患者血清二胺氧化酶活性和总IgE检测及意义[J].天津医药,2011,39(6):514-516. |
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| 作者姓名： | 张敏 李桂珍 宋蒙蒙 张理涛 |
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| 作者单位： | 1. 天津医科大学,300070
2. 天津市长征医院 |
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| 摘 要： | 目的:探讨二胺氧化酶(DAO)活性改变和血清总IgE水平在慢性荨麻疹发病中的意义。方法:采用分光光度法和酶联免疫吸附法测定68例慢性荨麻疹患者和54例健康对照者血清中DAO的活性及血清总IgE水平,并将其活性与病情程度和评分进行相关性分析。结果:慢性荨麻疹组血清DAO的活性在3个不同的时点均低于健康对照组,2组患者血清DAO活性时间效应、组间比较差异均有统计学意义(P<0.01),且分组与时间有交互作用(P<0.01);患者血清DAO活性与其病情的轻、中、重度存在正相关(P<0.05)。慢性荨麻疹患者和健康者在血清总IgE水平上差异有统计学意义(P<0.01),且当血清总IgE≥175IU/mL时,其与病情分级成正相关(P<0.05)。结论:慢性荨麻疹患者血清DAO活性降低及血清总IgE水平过高,可能与其慢性病程及严重程度有关。
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| 关 键 词： | 荨麻疹 慢性病 胺氧化酶(含铜) 组胺 IgE |
Detection and Significance of Serum Diamine Oxidase Activity and Total IgE in Chronic Urticaria Patients |
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| ZHANG Min,LI Guizhen,SONG Mengmeng,ZHANG Litao.Detection and Significance of Serum Diamine Oxidase Activity and Total IgE in Chronic Urticaria Patients[J].Tianjin Medical Journal,2011,39(6):514-516. |
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| Authors: | ZHANG Min LI Guizhen SONG Mengmeng ZHANG Litao |
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| Institution: | ZHANG Min,LI Guizhen,SONG Mengmeng,ZHANG LitaoTianjin Medical University,Tianjin 300070,China |
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| Abstract: | Objective: To detect the serum activity of diamine oxidase and the total serum IgE levels in chronic urticaria patients, and the significance thereof. Methods: The serum levels of diamine oxidase activity and the total serum IgE were determined by spectrophotometry and enzyme-linked immunosorbent assay in 68 patients with chronic urticaria and 54 healthy controls. The relationship of the activity and the urticaria severity was compared using linear correlation. Results: The serum levels of diamine oxidase a... |
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| Keywords: | IgE |
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