| 环氧化酶-2与脉络膜新生血管 |
| |
| 引用本文： | 蔡岩,王雨生. 环氧化酶-2与脉络膜新生血管[J]. 眼科研究, 2010, 28(1): 86-89. DOI: 10.3969/j.issn.1003-0808.2010.01.023 |
| |
| 作者姓名： | 蔡岩 王雨生 |
| |
| 作者单位： | 第四军医大学西京医院眼科,全军眼科研究所,西安,710032 |
| |
| 摘 要： | 脉络膜新生血管（CNV）是引起视力严重损害的常见原因之一，其发生发展是一个多因子调控、多细胞参与的复杂过程。环氧化酶-2（COX-2）是诱导型环氧化酶，是前列腺素生物合成途径的关键酶。COX-2通过调节血管内皮生长因子（VEGF）的合成及生理功能的发挥、内皮细胞的移行和凋亡，在新生血管的形成过程中起重要作用。近期研究证实，COX-2参与了CNV的形成过程，其抑制剂能够抑制CNV的发生发展，为预防和治疗CNV性疾病提供了新的方向。
|
| 关 键 词： | 脉络膜新生血管 环氧化酶-2 血管内皮生长因子 |
Cyclooxygenase-2 and choroidal neovascularization |
| |
| Cai Yan,Wang Yusheng. Cyclooxygenase-2 and choroidal neovascularization[J]. Chinese Ophthalmic Research, 2010, 28(1): 86-89. DOI: 10.3969/j.issn.1003-0808.2010.01.023 |
| |
| Authors: | Cai Yan Wang Yusheng |
| |
| Affiliation: | Cai Yan, Wang Yusheng. (Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University of PLA ,Xi＇ an 710032, China) |
| |
| Abstract: | Choroidal neovascularization(CNV)is one of common causes of vision loss.The pathogenesis and development of CNV are a comprehensive process which is regulated by multiple factors and cytokines.Cyclooxygenase-2(COX-2)is an inducible isoform of cyclooxygenase and rate limiting enzyme in the prostaglandin biosynthesis pathway.COX-2 plays an important role in neovascularization by modulating vascular endothelial growth factor(VEGF),migration and apoptosis of endothelial cell.Recently,some experimental studies demonstrated that COX-2 involves in the information of CNV and the inhibitor of COX-2 can suppress CNV.These results provide a new prospect for the prevention and treatment of the CNV.Biological characteristics of COX-2 and its relationship with CNV are reviewed in this article. |
| |
| Keywords: | choroidal neovascularization cyclooxygenase-2 vascular endothelial growth factor |
| 本文献已被 维普 万方数据 等数据库收录！ |
