| 环氧化酶-2与脉络膜新生血管 |
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| 引用本文： | 蔡岩,王雨生.环氧化酶-2与脉络膜新生血管[J].眼科研究,2010,28(1):86-89. |
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| 作者姓名： | 蔡岩 王雨生 |
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| 作者单位： | 第四军医大学西京医院眼科,全军眼科研究所,西安,710032 |
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| 摘 要： | 脉络膜新生血管（CNV）是引起视力严重损害的常见原因之一，其发生发展是一个多因子调控、多细胞参与的复杂过程。环氧化酶-2（COX-2）是诱导型环氧化酶，是前列腺素生物合成途径的关键酶。COX-2通过调节血管内皮生长因子（VEGF）的合成及生理功能的发挥、内皮细胞的移行和凋亡，在新生血管的形成过程中起重要作用。近期研究证实，COX-2参与了CNV的形成过程，其抑制剂能够抑制CNV的发生发展，为预防和治疗CNV性疾病提供了新的方向。
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| 关 键 词： | 脉络膜新生血管 环氧化酶-2 血管内皮生长因子 |
Cyclooxygenase-2 and choroidal neovascularization |
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| Cai Yan,Wang Yusheng.Cyclooxygenase-2 and choroidal neovascularization[J].Chinese Ophthalmic Research,2010,28(1):86-89. |
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| Authors: | Cai Yan Wang Yusheng |
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| Institution: | Cai Yan, Wang Yusheng. (Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University of PLA ,Xi＇ an 710032, China) |
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| Abstract: | Choroidal neovascularization(CNV)is one of common causes of vision loss.The pathogenesis and development of CNV are a comprehensive process which is regulated by multiple factors and cytokines.Cyclooxygenase-2(COX-2)is an inducible isoform of cyclooxygenase and rate limiting enzyme in the prostaglandin biosynthesis pathway.COX-2 plays an important role in neovascularization by modulating vascular endothelial growth factor(VEGF),migration and apoptosis of endothelial cell.Recently,some experimental studies demonstrated that COX-2 involves in the information of CNV and the inhibitor of COX-2 can suppress CNV.These results provide a new prospect for the prevention and treatment of the CNV.Biological characteristics of COX-2 and its relationship with CNV are reviewed in this article. |
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| Keywords: | choroidal neovascularization cyclooxygenase-2 vascular endothelial growth factor |
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