贝复济（bFGF）促进拔牙创早期愈合的动物实验研究

目的：探讨碱性成纤维细胞生长因子（bFGF)在拔牙创早期愈合过程中的作用。方法：采用8只家犬拔牙创动物模型，拔牙后前5天，在一侧拔牙创局部喷涂贝复济，为实验组，每日三次（每次约含bFGF 300AU)，另一侧不作处理为对照组。拔牙后0，5，7，10天测量创口面积，第7天和14天各处死一组动物作组织学观察。结果：实验组拔牙后早期的创口面积与对照组之间存在显著性差异（P＜0．05），组织学观察其创口内新骨形成数目比对照组多，成骨速度较对照组快。结论：贝复济（bFGF)具有显著促进拔牙创成纤维细胞增殖及肉芽组织和上皮细胞生长，有利于牙槽新骨形成的作用，从而有效地促进了拔牙创的早期愈合。

Basic Fibroblast Growth Factor Accelerates Wound Healing of Tooth Extraction

Objective: To evaluate the effect of basic fibroblast growth factor (bFGF) on the healing process after tooth extractoin. Methods: Eight dogs were selected as animal models.One side wound of each animal was sprayed with bFGF (300AU/time) three times a day for five days post_extraction, while the other side with no treats as control. The wound area was measured, at 5, 7, 10 days, histological examination was observed 7, 14 days after tooth extraction. Results: There was a significant difference of the wound areas between two groups at early stage after tooth extraction (P<0.05). Histological observation confirmed the quantity was more and the speed of new bone formation was quicker in experimental groups than the controls. Conclusions: bFGF could effectively stimulated proliferation and differentiation of soft and bone tissue cells during the early wound healing of extraction.