Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy |
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Authors: | Thijssen Victor L J L Postel Ruben Brandwijk Ricardo J M G E Dings Ruud P M Nesmelova Irina Satijn Sietske Verhofstad Nicole Nakabeppu Yusaku Baum Linda G Bakkers Jeroen Mayo Kevin H Poirier Françoise Griffioen Arjan W |
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Affiliation: | Angiogenesis Laboratory, Research Institute for Growth and Development (GROW), Department of Pathology, University Maastricht, 6202A2 Maastricht, The Netherlands. |
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Abstract: | We describe that galectin-1 (gal-1) is a receptor for the angiogenesis inhibitor anginex, and that the protein is crucial for tumor angiogenesis. gal-1 is overexpressed in endothelial cells of different human tumors. Expression knockdown in cultured endothelial cells inhibits cell proliferation and migration. The importance of gal-1 in angiogenesis is illustrated in the zebrafish model, where expression knockdown results in impaired vascular guidance and growth of dysfunctional vessels. The role of gal-1 in tumor angiogenesis is demonstrated in gal-1-null mice, in which tumor growth is markedly impaired because of insufficient tumor angiogenesis. Furthermore, tumor growth in gal-1-null mice no longer responds to antiangiogenesis treatment by anginex. Thus, gal-1 regulates tumor angiogenesis and is a target for angiostatic cancer therapy. |
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