| 黄芩素自微乳的制备及大鼠体内生物利用度研究 |
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| 引用本文： | 柯学,严菲,胡一桥. 黄芩素自微乳的制备及大鼠体内生物利用度研究[J]. 中国新药杂志, 2010, 0(5) |
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| 作者姓名： | 柯学 严菲 胡一桥 |
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| 作者单位： | 中国药科大学药剂教研室;南京大学生命科学学院;江苏省食品药品检验所; |
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| 基金项目： | 重大新药创制科技重大专项(2009ZX09310-004) |
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| 摘 要： | 目的:制备黄芩素自微乳化制剂(SMEDDS),考察其大鼠体内生物利用度。方法:采用伪三元相图法筛选自微乳的油相、表面活性剂及助表面活性剂;采用HPLC法测定大鼠血浆中药物浓度,与原料比较,对黄芩素自微乳进行大鼠体内生物利用度评价。结果:通过使用混合油相、混合表面活性剂及助表面活性剂,可获得较为理想的黄芩素自微乳。大鼠体内血药浓度-时间曲线结果表明,黄芩素自微乳的AUC是原料的3.77倍,且药时曲线的形状发生一定的改变。结论:自微乳系统可显著增加黄芩素的溶解度,有利于提高口服生物利用度,且自微乳可能改变其胃肠道吸收行为。
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| 关 键 词： | 黄芩素 自微乳 生物利用度 |
Preparation of baicalein self-microemulsifying drug delivery systems and oral bioavailability in rat |
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| KE Xue,,YAN Fei,HU Yi-qiao. Preparation of baicalein self-microemulsifying drug delivery systems and oral bioavailability in rat[J]. Chinese Journal of New Drugs, 2010, 0(5) |
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| Authors: | KE Xue YAN Fei HU Yi-qiao |
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| Affiliation: | KE Xue1,2,YAN Fei3,HU Yi-qiao2(1 Department of Pharmaceutics,China Pharmaceutical University,Nanjing 210009,China,2 School of Life Science,Nanjing University,Nanjing 210093,3 Jiangsu Institute for Food , Drug Control,Nanjing 210008,China) |
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| Abstract: | Objective:To prepare baicalein self-microemulsifying drug delivery systems(SMEDDS) and study its oral bioavailability in rat.Methods:The pseudo-ternary phase diagrams were constructed to evaluate the effect of different oils,surfactants and cosurfactants.The baicalein concentration in rat plasma was determined by a HPLC method.,The oral bioavailability of SMEDDS in rats was studied compared with the pure baicalein.Results: A good SMEDDS of baicalein was obtained by using composite oils,composite surfactants... |
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| Keywords: | baicalein(BA) self-microemulsifying drug delivery systems(SMEDDS) bioavailability |
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