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红外光谱法和X-射线粉末衍射法研究棉酚的多晶型
引用本文:袁锡炳,姜德和,沈海葆,丁洪亮. 红外光谱法和X-射线粉末衍射法研究棉酚的多晶型[J]. 药学学报, 1991, 26(2): 152-155
作者姓名:袁锡炳  姜德和  沈海葆  丁洪亮
作者单位:南京药物研究所,南京药物研究所,南京中医学院,南京药物研究所 南京 210009,南京 210009,南京 210009
摘    要:棉酚是棉子中的一种色素,具有广泛生理活性。棉酚、醋酸棉酚、甲酸棉酚曾初步试用于男性节育,但有一定毒副作用,影响了临床进一步试用。目前国内外学者仍在进一步研究。棉酚的结构式如下:

收稿时间:1989-11-08

STUDY ON POLYMORPHISM OF GOSSYPOL BY INFRARED SPECTROPHOTOMETRY AND X-RAY DIFFRACTION
XB Yuan,DH Jiang,HB Shen and HL Ding. STUDY ON POLYMORPHISM OF GOSSYPOL BY INFRARED SPECTROPHOTOMETRY AND X-RAY DIFFRACTION[J]. Acta pharmaceutica Sinica, 1991, 26(2): 152-155
Authors:XB Yuan  DH Jiang  HB Shen  HL Ding
Affiliation:Nanjing Institute of Materia Medica.
Abstract:The polymorphism of gossypol has been investigated by IR spectrophotometry and X-ray diffraction. Nine samples of gossypol crystallized from mixed solvent of ether, ethanol and water (1:2:2), five samples from chloroform and ten samples from petroleum ether (bp 60-90 degrees C) were determined. Significant differences in the infrared spectra of gossypol crystallized from three solvents were observed near 3500 cm-1. The spectrum of gossypol crystallized from mixed solvent of ether, ethanol and water (mp 183-184 degrees C) showed bands at 3500 (sh), 3470, 3375 cm-1; that from chloroform (mp 198-199 degrees C) at 3455, 3415 (sh) cm-1 and that from petroleum ether (mp 213-214 degrees C) at 3510, 3495, 3430 (sh), 3410 cm-1. Moreover, the spectra of the three forms of gossypol showed slightly different bands at 780 and 600-400 cm-1. Gossypol crystallized from the three solvents showed the same infrared spectra after being crystallized from acetone. Significant differences in the X-ray diffraction pattern of gossypol crystallized from the three solvents were also observed. Angles, intensities and D-values of most of the X-ray diffraction peaks were listed.
Keywords:Gossypol  Polymorphism  Infrared spectrophotometry  X-ray diffraction
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