儿童铅毒性临床和实验研究进展

近年来,铅毒性逐渐成为一个敏感话题.儿童常常处在慢性低水平的环境铅暴露中,铅对儿童的危害是一个剂量-效应连续的过程,累及神经、血液、消化、泌尿、免疫、内分泌等全身多系统并影响生长发育.该文回顾多年来国内外对铅毒性的研究成果,从铅毒性的生物学标志物、体内铅的检测方法、临床诊断、干预措施以及铅毒性实验研究中使用的体内外模型等多方面进行综述,为深入研究铅毒性提供科学依据.

Progress in Clinical and Experimental Researches of Children Lead Poisoning

In recent years,lead poisoning has gradually become an important public health issue.Usually,children are facing a chronic low-level environmental lead exposure.The damage of lead for children is a dose-effect continual process,involving in nerve,blood,digestive,urinary,immune,endocrine and many other systems,and can affect children's growth.The recent researches on children lead poisoning were reviewed and the biological markers of lead poisoning,detection method of lead in vivo.clinical diagnosis,interventions and models in vitro and in vivo in studies of lead poisoning were summarized.This article would offers scientific researchers effective and convenient scientific basis for further study of the lead toxicity.