纳米银的抗菌原理及生物安全性研究进展

由于纳米银独特的抗菌特性,使其得到了广泛的应用,极大地增加了人们接触纳米银的机会,对其安全性进行评价就成为迫切需要解决的问题.迄今为止,国内外对纳米银的毒性研究在方法上主要集中于形态学、线粒体功能测定、细胞增殖、酶活力等细胞毒性的检测,整体水平的毒性检测也有报道,而缺乏从分子水平进行机制方面的探讨研究.该文就纳米银的抗菌原理及其生物安全性的研究现状进行综述,并对纳米银在毒理学研究的发展方向进行了展望.

Progress in Research on Antibacterial Mechanism and Biological Safety of Silver Nanoparticles

The antibacterial property of silver nanoparticles has resulted in their widespread application in many fields,so the chance of silver nanoparticles exposure for human increased greatly.Thus,there is urgent need to assess the safety of such particle.So far,most toxicological studies of siner nanoparticles mainly focus on the cytotoxicity using different examination endpoint such as morphology,mitochondrial function,cell proliferation,enzyme activity,and so on.In addition,the in vitro studies on the toxicity of silver nanopoarticles are also reported,few of the study on molecule mechanism of toxicity was reported.This review provided a summary of antibacterial mechanism of silver nanoparticles and the current research situation of the safety.The future research direction of toxicological study of silver nanoparticles is also prospected based on the current knowledge.