| D4-鸟苷酸解离抑制因子在肺癌发病机制中的研究进展 |
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| 引用本文： | 罗新岳,胡瑞成,戴爱国.D4-鸟苷酸解离抑制因子在肺癌发病机制中的研究进展[J].国际肿瘤学杂志,2014(3):206-208. |
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| 作者姓名： | 罗新岳 胡瑞成 戴爱国 |
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| 作者单位： | [1]南华大学附属省马王堆医院,长沙410016 [2]湖南省老年医学研究所呼吸疾病研究室,长沙410016 |
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| 基金项目： | 国家自然科学基金（81070035） |
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| 摘 要： | D4-鸟苷酸解离抑制因子（GDI）是RhoGDP解离抑制因子家族的主要成员之一，抑制Rho蛋白与GDP解离，参与细胞的收缩、黏附、迁移、增殖、凋亡等多种生物学行为。目前已证实D4-GDI参与了肺癌等多种呼吸系统疾病的病理生理过程，干预D4-GDI的表达能够改善这些疾病的病理改变与预后。
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| 关 键 词： | 细胞凋亡 炎症 信号通路 肺肿瘤 D4-GDI |
Research progress of D4-GDI in the pathogenesis of lung cancer |
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| Luo Xinyue,Hu Ruicheng,Dai Aiguo.Research progress of D4-GDI in the pathogenesis of lung cancer[J].Journal of International Oncology,2014(3):206-208. |
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| Authors: | Luo Xinyue Hu Ruicheng Dai Aiguo |
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| Institution: | . University of South China Affiliated Provincial Mawangdui Hospital, Changsha 410016, China |
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| Abstract: | As one of the main members of the Rho GDI dissociation inhibitory factors, D4-GDI inhibits the dissociation of Rho protein and GDP, which is also involved in a wide range of celluar functions, such as cell contraction, adhesion, migration, proliferation and apoptosis. Recently, accumulating evidence has been suggested that IM-GDI is involved in the pathogenesis of several pulmonary diseases, such as lung cancer. Intervention of D4-GDI expression may improve the pathological changes and prognosis of these diseases. |
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| Keywords: | Apoptosis Inflammation Signaling pathway Lung neoplasms D4-GDI |
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