| 唑来膦酸在乳腺癌中抗肿瘤作用的研究现状 |
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| 引用本文： | 陈晨,孙蔚莉,陈嘉,霍介格.唑来膦酸在乳腺癌中抗肿瘤作用的研究现状[J].国际肿瘤学杂志,2014(3):196-199. |
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| 作者姓名： | 陈晨 孙蔚莉 陈嘉 霍介格 |
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| 作者单位： | [1]南京中医药大学第一临床医学院,210029 [2]江苏省肿瘤医院肿瘤内科 ,210029 [3]江苏省中西医结合医院肿瘤内科,210029 |
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| 基金项目： | 江苏省肿瘤医院院级科研项目（ZM201204） |
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| 摘 要： | 唑来膦酸作为第3代双膦酸盐药物已广泛用于乳腺癌骨转移相关事件的防治。唑来膦酸在乳腺癌中具有抗肿瘤治疗作用。唑来膦酸通过抑制乳腺癌细胞的增殖和诱导细胞凋亡，降低肿瘤细胞的迁移、侵袭能力，防止有利于肿瘤生长的骨微环境的形成，抑制肿瘤新生血管形成，调节免疫等多种途径直接或间接发挥其抗肿瘤作用，与放化疗及内分泌等辅助治疗有序贯协同增效作用。唑来膦酸在乳腺癌患者辅助治疗中的协同抗肿瘤作用也在几项相关的前瞻性临床试验中进行。
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| 关 键 词： | 抗肿瘤药 乳腺肿瘤 唑来膦酸 |
Progress on antitumor effects of zoledronic acid in breast cancer |
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| Chen Chen,Sun Weili,Chen Jia,Huo Jiege.Progress on antitumor effects of zoledronic acid in breast cancer[J].Journal of International Oncology,2014(3):196-199. |
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| Authors: | Chen Chen Sun Weili Chen Jia Huo Jiege |
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| Institution: | . First School of Clinical Medicine, Nanfing University of Traditional Chinese Medicine, Nanjing 210029, China |
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| Abstract: | As the third-generation bisphosphonate, zoledronic acid （ZOL） has been widely used for the treatment of skeletal-related events in breast cancer. Previous studies have demonstrated that ZOL has anti- tumor activitie in breast cancer. ZOL can induce direct and indirect antitumor activities through inducing apop- tosis, inhibiting the proliferation, adhesion and invasion formation of bone microenvironment which is conducive to tumor growth, besides inhibiting angiogensis and modulating immune response. Also evidences of synergistic antitumor effects are found when ZOL combines with radiotherapy and chemotherapy, endocrine, and targeted drugs. The observed improvement in antitumor effects by using combination therapy with ZOL in breast cancer is currently being verified through additional clinical trials. |
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| Keywords: | Antineoplastic agents Breast neoplasms Zoledronic acid |
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