| 通心络对自发性高血压大鼠血浆NO、ET及血管平滑肌iNOS表达的影响 |
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| 引用本文： | 李必强,姚恩辉. 通心络对自发性高血压大鼠血浆NO、ET及血管平滑肌iNOS表达的影响[J]. 福建中医学院学报, 2009, 19(4): 53-55,65 |
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| 作者姓名： | 李必强 姚恩辉 |
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| 作者单位： | 福建医科大学附属协和医院,福建,福州,350001 |
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| 摘 要： | 目的 观察通心络对自发性高血压大鼠(SHR)血压、血浆内皮素(ET)、一氧化氮(NO)、血管紧张素Ⅱ(Ang Ⅱ)以及主动脉血管平滑肌组织(VSM)iNOS mRNA表达的变化. 方法 30只12周龄雄性SHR大鼠,随机分成3组,每组10只,分别为空白对照组、通心络小剂量组、大剂量组,年龄、性别配对的正常雄性WKY大鼠作为时照.各给药组均采用灌胃法给药,对照组给予等量蒸馏水.治疗12周.放免法测定血浆ET、Ang Ⅱ浓度,NO浓度采用硝酸还原酶法测定,用RT-PCR检测VSM组织iNOS mRNA表达水平. 结果 与未治疗组SHR相比,大、小剂量通心络治疗均能在一定程度上抑制SHR大鼠血压升高(P<0.05);小剂量通心络治疗可降低血浆ET浓度(P<0.05),升高NO浓度(P<0.05),Ang Ⅱ浓度无明显变化(P>0.05),VSM iNOS mRNA表达增强(P<0.05);大剂量通心络治疗可使血浆ET明显降低(P<0.01),Ang Ⅱ浓度下调(P<0.05),NO浓度显著升高(P<0.01),VSM iNOS mRNA表达显著增强(P<0.01). 结论 通心络治疗能有效降低SHR大鼠血浆ET、Ang Ⅱ水平,促进VSM组织iNOS mRNA表达,增加血浆NO浓度,抑制血压的升高.
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| 关 键 词： | 通心络 自发性高血压 内皮素 一氧化氮 一氧化氮合酶 血管紧张素Ⅱ 大鼠 |
Effect of Tongxinluo on Expression of Plasma NO, Endothelin and iNOS mRNA in Vascular Smooth Muscle in Spontaneously Hypertensive Rats |
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| LI Bi-qiang,YAO En-hui. Effect of Tongxinluo on Expression of Plasma NO, Endothelin and iNOS mRNA in Vascular Smooth Muscle in Spontaneously Hypertensive Rats[J]. Journal of Fujian College of Traditional Chinese Medicine, 2009, 19(4): 53-55,65 |
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| Authors: | LI Bi-qiang YAO En-hui |
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| Affiliation: | Union Hospital;Fujian Medical University;Fuzhou;Fujian 350001;China |
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| Abstract: | Objective To evaluate the effect of Tongxinluo on blood pressure,plasma endothelin(ET),NO,angiotensin II(ANG II) and nitric oxide synthase(iNOS) mRNA expression in vascular smooth muscle(VSM) in spontaneously hypertensive rats(SHRs).Methods 12-week-old male SHRs were divided into Tongxinluo low-dose group(n=10),Tongxinluo high-dose group(n=10),and age and sex matched Wistar Kyoto rats were set as control group(n=10).Tongxinluo groups were gastric perfused with Tongxinluo respectively and the control group w... |
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| Keywords: | Tongxinluo hypertensive ET NO nitric oxide synthase rats |
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