| 比较基因组杂交研究鼻咽癌遗传变异 |
| |
| 引用本文： | 李忠花,王璐,张小慧,张丽君,张必成,余鹰,曾朝阳,周鸣,黄薇,陈竺,陈赛娟,李桂源. 比较基因组杂交研究鼻咽癌遗传变异[J]. 中华医学遗传学杂志, 2001, 18(5): 338-342 |
| |
| 作者姓名： | 李忠花 王璐 张小慧 张丽君 张必成 余鹰 曾朝阳 周鸣 黄薇 陈竺 陈赛娟 李桂源 |
| |
| 作者单位： | 1. 中南大学湘雅医学院肿瘤研究所
2. 上海第二医科大学附属瑞金医院血液研究所及遗传教研室 |
| |
| 基金项目： | 国家"863”项目基金(Z19-01-01-03和102-10-01-05);国家"973”项目基金(G1998051008) |
| |
| 摘 要： | 目的 了解鼻咽癌遗传学改变的特征。方法 应用比较基因组杂交检测20例鼻咽癌基因组的不平衡即DNA的丢失或扩增。结果 鼻咽癌常见的扩增的染色体是1q、2、3q、7q、8q、12;常见的缺失的染色体为3p、9p、11q、16q。结论 鼻咽癌细胞中存在多条染色体拷贝数的改变,由此引起相应瘤基因的扩增和抑癌基因的丢失可能参与了鼻咽癌的发生、发展。
|
| 关 键 词： | 鼻咽癌 比较基因组杂交 抑瘤基因 瘤基因 |
| 修稿时间： | 2000-10-23 |
Chromosomal aberration analyzed by comparative genomic hybridization in nasopharyngeal carcinoma |
| |
| LI Zhonghua ,WA NG Lu ,ZHANG Xiaohui ,ZHANG Lijun ,ZHANG Bichen ,YU Ying ,ZENG Z haoyang ,ZHOU Ming ,HUANG Wei ,CHEN Zhu ,CHEN Saijuan ,LI Guiyuan .. Chromosomal aberration analyzed by comparative genomic hybridization in nasopharyngeal carcinoma[J]. Chinese journal of medical genetics, 2001, 18(5): 338-342 |
| |
| Authors: | LI Zhonghua WA NG Lu ZHANG Xiaohui ZHANG Lijun ZHANG Bichen YU Ying ZENG Z haoyang ZHOU Ming HUANG Wei CHEN Zhu CHEN Saijuan LI Guiyuan . |
| |
| Affiliation: | Tumor Cellular Genetic Lab, Cancer Research Institute, Xiang Ya School of Medicine, Central South University, Changsha, Hunan, 410078 P.R. China. ligy@public.cs.hn.cn |
| |
| Abstract: | Objective To identify genetic alteration in pri ma ry sporadic nasopharyngeal carcinoma (NPC) in Hunan. Methods Comp a rative genomic hybridization was applied to investigate the genomic imbalance in a series of 20 cases of primary nasopharyngeal carcinomas.Results The common chromosomal alterations included gains of chromosomes 1q, 2, 3q, 7q,8q,12 as well as losses of chromosomes 3p, 9p, 11q, 16q. Conclusion There are multiple regions of chromosomes with copy number changes in NPC. Th e tumor suppressor genes and oncogenes on these regions may be involved in the d evelopment and progress of nasopharyngeal carcinoma. |
| |
| Keywords: | nasopharyngeal carcinoma comparative genomic hy bridization tumor suppressor gene oncogene |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
