Comparative analysis of the predictive power of different endothelial progenitor cell phenotypes on cardiovascular outcome |
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Authors: | Schwartzenberg Shmuel Afek Arnon Charach Gideon Rubinstein Ardon Ben-Shoshan Yossi Kissil Sarina Maisel-Auslender Sofia Keren Gad George Jacob |
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Institution: | Shmuel Schwartzenberg, Jacob George, Department of Cardiology, Kaplan Medical Center, affiliated to the Hebrew University, Rehovot 76100, Israel;Arnon Afek, Gideon Charach, Ardon Rubinstein, Yossi Ben-Shoshan, Sarina Kissil, Sofia Maisel-Auslender, Gad Keren, Department of Cardiology, Tel Aviv Sourasky Medical Center, Affiliated to the Tel Aviv University, Sackler School of Medicine, Tel Aviv 64239, Israel |
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Abstract: | AIM: To compare the predictive power of different endothelial progenitor cell (EPC) phenotypic markers for future cardiovascular events.METHODS: Peripheral blood was collected from 76 consecutive patients with acute coronary syndromes (ACS) who underwent percutaneous coronary intervention in our institute. The various EPC phenotypes of peripheral blood mononuclear cells were CD34+CD133+, CD34+KDR+, and CD 133+KDR+. The outcome endpoint included cardiovascular mortality, recurrent ACS, and hospitalization for decompensated heart failure during a 24-mo follow-up period.RESULTS: CD34+CD133+ cells (P = 0.034), but not CD34+KDR+ (P = 0.35) or CD 133+KDR+ cells (P = 0.19), were found to predict recurrent ACS. We found no correlation between EPCs measured by any of the three phenotypic combinations of accepted CD markers and the total combination of these separate outcomes.CONCLUSION: The EPC CD34+CD133+ phenotype, but not the CD34+KDR+ or the CD 133+KDR+ phenotypes, is predictive of future adverse cardiovascular outcomes. |
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Keywords: | Stem cells Endothelial progenitor cells Acute coronary syndrome Biomarkers |
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