冠心病患者基质金属蛋白酶1基因多态性

目的 研究基质金属蛋白酶1基因多态性与冠心病的关系。方法 运用聚合酶链反应检测62例冠心病患者（急性冠状动脉综合征35例，稳定型心绞痛患者27例）及31例正常对照者基质金属蛋白酶1基因型，并运用高频超声技术检测双侧颈动脉。结果 急性冠状动脉综合征患者基质金属蛋白酶1基因2G／2G型、2G等住基因频率均明显高于稳定型心绞痛患者及正常对照者，颈动脉脂质型斑块基质金属蛋白酶1基因2G／2G型、2G等位基因频率均明显高于纤维型和钙化型斑块，基因型及等位基因频率分布差异均有统计学意义。结论 急性冠状动脉综合征、稳定型心绞痛患者及正常对照者基质金属蛋白酶1基因分布存在不同。2G／2G型、2G等位基因与动脉粥样硬化斑块不稳定性可能有关。

A Study on the Relationship between Polymorphism of Matrix Metalloproteinase 1 and Coronary Heart Disease

Aim To investigate the association between polymorphism of matrix metalloproteinase 1(MMP-1) and coronary heart disease.Methods This study enrolled 35 patients with acute coronary syndrome,27 patients with stable angina(SA),31 normal volunteers.The carotid arteries were performed with echocardiography.With PCR,genotypes of MMP-1 were scored according to the patterns of DNA bands.Results The frequency of MMP-1 2G/2G type and allele T was significantly higher in ACS group than SA group and control group.The frequency of MMP-1 2G/2G type and allele T was significantly higher in fatty plaque than fibrous plaque and calcify plaque.Conclusion There was association between the acute coronary syndrome and the 2G/2G type of MMP-1.