Statistical estimations in pharmacokinetics |
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| Authors: | Harold G. Boxenbaum Sidney Riegelman Robert M. Elashoff |
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| Affiliation: | (1) Present address: Department of Biochemistry and Drug Metabolism, Hoffmann-LaRoche, Inc., 07110 Nutley, New Jersey;(2) Department of Pharmaceutical Chemistry, University of California, San Francisco Medical Center, 94143 San Francisco, California;(3) Department of Informational Systems, University of California, San Francisco Medical Center, 94143 San Francisco, California |
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| Abstract: | Several important statistical aspects of pharmacokinetic analyses by digital computer are discussed. These include selection of appropriate equations, weighting of data, precision of parameter estimates, comparisons of parameters, analysis of weighted residuals, and criteria useful in the selection of particular models. Data obtained after administration of isoniazid and isonicotinuric acid to man are analyzed to illustrate the usefulness of the discussed methods. |
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| Keywords: | pharmacokinetics computer program NONLIN data weighting isoniazid |
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