Impact of oral anticoagulation on morbidity of transurethral resection of the prostate |
| |
Authors: | Aur??lien Descazeaud Gregoire Robert Souhil Lebdai Alain Bougault Abdel Rahmene Azzousi Olivier Haillot Marian Devonec Marc Fourmarier Christian Saussine Nicolas Barry-Delongchamps Alexandre de la Taille |
| |
Institution: | 1. Department of Urology, Service de chirurgie urologique, Hopital Dupuytren CHU de Limoges, 2 av Martin Luther King, 87042, Limoges, France 2. Facult?? de m??decine de Limoges UA 3842, Universit?? de Limoges, 2 rue du Dr Marcland, 87025, Limoges, France 3. CTMH-AFU, Maison de l??urologie, 61 rue de Vaugirard, 75006, Paris, France 4. INSERM U955 Eq07, Cr??teil, France 5. CHU Bordeaux, Department of Urology, University Bordeaux 2 Victor Segalen, Bordeaux Cedex, France 6. Department of Urology, CHU Angers, Angers Cedex, France 7. Department of Urology, CHU de Tours, Tours, France 8. Department of Urology, CHU Lyon Sud, Pierre?\B??nite, France 9. Department of Urology, CH, Aix en Provence, France 10. Department of Urology, CHU Strasbourg, Strasbourg, France 11. Department of Urology, CHU Cochin APHP, Paris, France 12. Department of Urology, Assistance publique des Hopitaux de Paris, CHU Mondor, Cr??teil, France
|
| |
Abstract: | Aim To assess the impact of oral anticoagulation (OA) on morbidity of transurethral resection of the prostate (TURP). OA included warfarin and platelet aggregation inhibitors (PAI). Patients and Method Multicenter analysis of patients operated for symptomatic benign prostatic hyperplasia (BPH) by TURP. Patients under OA were compared to those with no OA. Results Out of 612 patients included in the analysis, 206 (33%) were on OA prior surgery (55 warfarin, 142 PAI, and 9 warfarin and PAI). No patient continued warfarin and clopidogrel during the operating period. Patients under OA were significantly older (75 vs. 71 yo, P?<?0.001), had larger prostate volume (56 vs. 49?ml, P?=?0.05), and had higher rate of bladder catheter prior surgery (26 vs. 17%, P?=?0.02). At 3?months follow-up, patients in the OA group had a higher weight of resected tissue (24 vs. 21.7?g, P?<?0.001), a longer duration of hospitalization (6.4 vs. 4.7?days P?<?0.001), a higher rate of bladder clots (13 vs. 4.7%, P?<?0.001), red cell transfusion (1.9 vs. 1.0%, P?=?0.026), late hematuria (15.0 vs. 8.4%, P?=?0.004), and thromboembolic events (2.4 vs. 0.7, P?=?0.02). In multivariable analysis, OA status was the sole independent parameter associated with bladder clots (P?=?0.004) and with late hematuria (P?=?0.03). Conclusion OA had a significant and independent impact on TURP outcome in terms of bleeding complications. This data could be used for treatment decision and for patient??s information prior BPH surgery. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|