血清肿瘤标志物的联合检测在肺癌诊断中的价值

目的：了解3种血清肿瘤标志物在肺癌诊断的应用价值，以提高肺癌的诊断率。方法：应用放射免疫技术，测定62例肺癌患者、43例肺良性疾病患者和正常对照的血清CYFRA2l—l、NSE、CEA的水平。结果：肺癌患者组的3种标志物CYFRA2l—l、NSE、CEA的水平明显高于肺良性疾病患者组和正常对照组(P＜0．01)。其中CYFRA2l—l、NSE、CEA的灵敏度分别为65．4％、29．8％、48．7％，但三者联合检测的灵敏度为94．3％，明显优于3种血清肿瘤标志物的单项测定。结论：血清CYFRA2l—l、NSE、CEA对肺癌的诊断有价值，建议临床工作中采用三者联合检测。

THE VALUE OF COMBINED DETECTION OF SERUM TUMOR MARKERS IN THE DIAGNOSIS OF LUNG CANCER

Objective: To evaluate the application of three tumor markers in diagnosing lung cancer to enhance the detection ratio. Methods: Using immunoradiometric assay, we measured the serum CYFRA21 1, NSE and CEA levels in 62 cases of lung cancer, 43 cases of benign pulmonary disease and 36 cases of normal controls. Results: The levels of CYFRA21 1, NSE and CEA in patients with lung cancer were significantly higher than those in group with benign lung disease and the control group( P <0.01). The sensitivity of CYFRA21 1, NSE, CEA for lung cancer were 65.4 %, 29.8 %, 48.7 %.But the sensitivity of the combined determination containing three tumor markers were 94.3 %, being higher than other in diagnosis for lung cancer.Conclusion:Serum CYFRA21 1,NSE,CEA were significantly valuable in diagnosis of lung cancer. It is suggested that the determination combined CYFRA21 1,NSE and CEA should be used in clinical work.